Updates in Surgery

, Volume 65, Issue 2, pp 161–164 | Cite as

Corticomedullary mixed tumor of the adrenal gland—a clinical and pathological chameleon: case report and review of literature

  • G. Donatini
  • S. Van Slycke
  • S. Aubert
  • B. Carnaille
Case Report


Adrenal tumors mostly present with specific and unique clinical features, regarding their endocrine metabolism. A 53-year-old man came to our Department for a left adrenal mass discovered incidentally. Biochemical and imaging findings were suspicious for a pheochromocytoma. The patient underwent a laparoscopic left adrenalectomy. A well-circumscribed 5.5-cm mass was removed. It was composed of adrenal cells intimately admixed with pheochromocytes. Immunohistochemical studies were positive both for cortical cells (inibin-α, synaptophysine and melan-A) and medullary cells (S-100 and chromogranine A). Final pathology was of corticomedullary mixed tumor (CMT). CMT is a rare tumor with 14 cases previously reported in literature, with wide variable biochemical behavior, such as his radiological and pathological features. Prevalence and actual malignant potential are yet unknown to our knowledge.


Conflict of interest



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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • G. Donatini
    • 1
    • 2
  • S. Van Slycke
    • 1
  • S. Aubert
    • 1
  • B. Carnaille
    • 1
  1. 1.Department of General and Endocrine SurgeryCHR HuriezLille CedexFrance
  2. 2.Lille CedexFrance

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