Tumor Biology

, Volume 37, Issue 10, pp 13039–13048 | Cite as

miRNA-regulated cancer stem cells: understanding the property and the role of miRNA in carcinogenesis

  • Chiranjib Chakraborty
  • Kok-Yong Chin
  • Srijit Das


Over the last few years, microRNAs (miRNA)-controlled cancer stem cells have drawn enormous attention. Cancer stem cells are a small population of tumor cells that possess the stem cell property of self-renewal. Recent data shows that miRNA regulates this small population of stem cells. In the present review, we explained different characteristics of cancer stem cells as well as miRNA regulation of self-renewal and differentiation in cancer stem cells. We also described the migration and tumor formation. Finally, we described the different miRNAs that regulate various types of cancer stem cells, such as prostate cancer stem cells, head and neck cancer stem cells, breast cancer stem cells, colorectal cancer stem cells, lung cancer stem cells, gastric cancer stem cells, pancreatic cancer stem cells, etc. Extensive research is needed in order to employ miRNA-based therapeutics to control cancer stem cell population in various cancers in the future.


Migration miRNA Stem cell Therapy Tumor 


Compliance with ethical standards

Conflicts of interest



UKM DLP grant-2014-009.


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Chiranjib Chakraborty
    • 1
  • Kok-Yong Chin
    • 2
  • Srijit Das
    • 3
  1. 1.Department of Bioinformatics, School of Computer and Information SciencesGalgotias UniversityUttar PradeshIndia
  2. 2.Department of PharmacologyUniversiti Kebangsaan Malaysia Medical CentreKuala LumpurMalaysia
  3. 3.Department of Anatomy, Faculty of MedicineUniversiti Kebangsaan Malaysia Medical CentreKuala LumpurMalaysia

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