Tumor Biology

, Volume 37, Issue 8, pp 11237–11247 | Cite as

JMJD1A promotes tumorigenesis and forms a feedback loop with EZH2/let-7c in NSCLC cells

  • Min Zhan
  • Feiqiu Wen
  • Lijuan Liu
  • Zebin Chen
  • Hong Wei
  • Honghao ZhouEmail author
Original Article


Lung cancer is the most common cause of cancer-related deaths worldwide, and non-small cell lung cancer (NSCLC) accounts for 80 to 85 % of all lung cancer. Although the standard treatment regimen has been established, long-term survival for NSCLC patients is still generally poor. The histone demethylase Jumonji domain containing 1A (JMJD1A) has been proposed as an oncogene in several types of human cancer, but its clinical significance and functional roles in NSCLC remain largely unclear. In the present study, JMJD1A was frequently upregulated in NSCLC compared with para-carcinoma tissues. JMJD1A knockdown significantly inhibited NSCLC cell growth, migration, and invasion in vitro and tumorigenesis in vivo. Further experiments demonstrated that JMJD1A knockdown could decrease the expression of EZH2, which has been shown to play a crucial role in the carcinogenesis of NSCLC and, in turn, increase the expression of anti-tumor microRNA let-7c. Also, let-7c directly targeted the 3′-untranslated regions of JMJD1A and EZH2. Taken together, JMJD1A could promote NSCLC tumorigenesis. JMJD1A/EZH2/let-7c constituted a feedback loop and might represent a promising therapeutic target for NSCLC.


JMJD1A EZH2 Let-7c Feedback NSCLC Tumorigenesis 



This work was supported by the 863 Project (No. 2012AA02A517), Medical Scientific Research Foundation of Guangdong Province (No. B2014362), and National Natural Science Foundation of China (No. 81260337).

Compliance with ethical standards

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Min Zhan
    • 1
  • Feiqiu Wen
    • 1
  • Lijuan Liu
    • 2
  • Zebin Chen
    • 1
  • Hong Wei
    • 1
  • Honghao Zhou
    • 3
    • 4
    • 5
    Email author
  1. 1.Shen Zhen Children’s HospitalShenzhenChina
  2. 2.Jiangxi Provincial Cancer HospitalNanchangChina
  3. 3.Department of Clinical Pharmacology, Xiangya HospitalCentral South UniversityChangshaChina
  4. 4.Institute of Clinical PharmacologyCentral South UniversityChangshaChina
  5. 5.Hunan Key Laboratory of PharmacogeneticsChangshaChina

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