Tumor Biology

, Volume 37, Issue 7, pp 9635–9648 | Cite as

Is cholesterol a mediator of cold-induced cancer?

  • Chandi C. MandalEmail author
  • Ankit Sharma
  • Mahaveer S. Panwar
  • James A. Radosevich
Original Article


Many factors such as smoking, obesity, and high fat have been either directly or indirectly linked to cancer deaths and/or incidences. Similarly, abnormal serum cholesterol levels have been assigned as a risk factor for cancer, but some studies show a discrepant result. To resolve this discrepancy, we have analyzed cholesterol data of 166 countries. Univariate analysis showed a positive correlation between serum average total cholesterol (ATC) and overall cancer mortality rate (CMR) [tau = 0.277, z = 5.19, p < 0.0001]. It was also observed that a similar positive correlation was found between ATC and different anatomical site-specific CMRs in lung, bladder, ovarian, breast, and pancreatic cancers. Our recent published data documented an existence of a negative correlation between average annual temperature (AAT) and overall CMR, as well as CMR of the abovementioned anatomical site-specific cancers. Statistical analysis further shows a negative correlation between AAT and ATC, similar to that of AAT and CMR. The resulting patterns of univariate analysis between AAT and CMR are almost identical with AAT and ATC, when this analysis was performed every 2 °C of AAT increment for all countries. Moreover, geographical location of the top 50 countries having the highest CMR is almost similar to the top 50 countries having the highest ATC. Similarly, the least 50 countries having the lowest CMR are located in the same geographical region, similar to the least 50 countries having the lowest ATC. These data along with other literature reports suggest that cholesterol could be a mediator of cold-induced cancer mortality.


Environmental temperature Cancer mortality rate Cholesterol Geographical location Cancer-causing factors 



Authors thank to Smita Majumder (Department of Mathematics, Central University of Rajasthan, India) for her support in data collection and statistical analysis. CCM is supported by UGC [30-49/2014 (BSR)], DBT [6242-P9/RGCB/PMD/DBT/CCML/2015], and Central University of Rajasthan, India.

Compliance with ethical standards

Conflicts of interest


Supplementary material

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Table S1 (PDF 291 kb)
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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2016

Authors and Affiliations

  • Chandi C. Mandal
    • 1
    Email author
  • Ankit Sharma
    • 1
  • Mahaveer S. Panwar
    • 2
  • James A. Radosevich
    • 3
  1. 1.Department of BiochemistryCentral University of RajasthanAjmerIndia
  2. 2.Department of StatisticsCentral University of RajasthanAjmerIndia
  3. 3.Department of Oral Medicine and Diagnostic Sciences, College of DentistryUniversity of Illinois at ChicagoChicagoUSA

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