Tumor Biology

, Volume 37, Issue 5, pp 6691–6699 | Cite as

Comparative analysis of basaloid and conventional squamous cell carcinomas of the esophagus: prognostic relevance of clinicopathological features and protein expression

  • Yukie Sato-KuwabaraEmail author
  • José Humberto T. G. Fregnani
  • Juliano Jampietro
  • Katia Cândido Carvalho
  • Carolina Parucce Franco
  • Wilson Luís da CostaJr.
  • Felipe J. F. Coimbra
  • Fernando Augusto Soares
Original Article


Basaloid squamous cell carcinoma (BSCC), a variant of squamous cell carcinoma (SCC), is a rare and aggressive epithelial malignancy which has been reported in only 0.1–11 % of primary esophageal carcinomas. In this study, a comparison of clinicopathological features and protein expression between esophageal BSCC (EBSCC) and conventional esophageal SCC (ESCC) cases from Brazil was performed in order to find factors that can be relevant to better characterize EBSCC. The expression of HER2, epidermal growth factor receptor (EGFR), Ki-67, and cyclins (A, B1, and D1) in 111 cases (95 ESCC and 16 EBSCC) was evaluated by immunohistochemistry using tissue microarray. When the clinicopathological data were compared, no significant difference was found between the two histological types. Although the difference is not significant (p = 0.055), the EGFR expression was more frequent in the conventional ESCC than in the EBSCC group. Our results indicate that the clinicopathological profiles of conventional ESCC and EBSCC are similar and provide no indicators for differences in prognosis between these two groups.


Basaloid squamous cell carcinoma EGFR HER2 Cyclins Ki-67 



The authors thank Carlos Ferreira Nascimento and Severino Ferreira da Silva for providing technical assistance. This study was supported by grants from the Fundação de Apoio a Pesquisa do Estado de São Paulo (FAPESP).

Compliance with ethical standards


This study was supported by grants from the Fundação de Apoio a Pesquisa do Estado de São Paulo (FAPESP 2010/19572-6).

Conflicts of interest


Supplementary material

13277_2015_4551_MOESM1_ESM.docx (55 kb)
Supplementary Table S1 (DOCX 55 kb)
13277_2015_4551_MOESM2_ESM.docx (59 kb)
Supplementary Table S2 (DOCX 58 kb)


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Yukie Sato-Kuwabara
    • 1
    Email author
  • José Humberto T. G. Fregnani
    • 2
  • Juliano Jampietro
    • 1
  • Katia Cândido Carvalho
    • 3
  • Carolina Parucce Franco
    • 4
  • Wilson Luís da CostaJr.
    • 4
  • Felipe J. F. Coimbra
    • 4
  • Fernando Augusto Soares
    • 5
    • 6
  1. 1.International Research CenterA.C. Camargo Cancer CenterSão PauloBrazil
  2. 2.Gynecologic Oncology Department, Fundação Pio XIIHospital do Câncer de BarretosBarretosBrazil
  3. 3.Obstetrics and Gynecology Department, Faculty of MedicineUniversity of São PauloSão PauloBrazil
  4. 4.Department of Abdominal SurgeryA.C. Camargo Cancer CenterSão PauloBrazil
  5. 5.Department of Anatomic PathologyA.C. Camargo Cancer CenterSão PauloBrazil
  6. 6.Department of Stomatology, School of DentistryUniversity of São PauloSão PauloBrazil

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