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Tumor Biology

, Volume 37, Issue 6, pp 7685–7692 | Cite as

The impact of coexistent Hashimoto’s thyroiditis on lymph node metastasis and prognosis in papillary thyroid microcarcinoma

  • Ning Qu
  • Ling Zhang
  • Dao-zhe Lin
  • Qing-hai JiEmail author
  • Yong-xue Zhu
  • Yu Wang
Research Article

Abstract

The impact of coexistent Hashimoto’s thyroiditis (HT) on lymph node metastasis (LNM) and prognosis in papillary thyroid microcarcinoma (PTMC) remains controversial. We evaluated the association of coexistent HT with clinicopathologic parameters, LNM, and prognosis by retrospectively reviewing a series of consecutive patients treated for PTMC at Fudan University Cancer Center from January 2005 to December 2010. Of all 1,250 patients with complete data for analysis, 364 (29.1 %) had coexistent HT (HT group) and 886 patients (70.9 %) had no evidence of HT (control group). The HT group had higher proportion of female (87.9 vs 70.1 %) patients, higher mean level of thyroid-stimulating hormone (TSH) (2.39 vs 2.00 mIU/L), and lower incidence of extrathyroidal extension (7.4 vs 11.7 %) than those in the control group. However, the incidence of LNM and recurrence was similar between the two groups, and HT was not associated with LNM and recurrence. A series of clinicopathologic factors identified for predicting LNM and recurrence in the control group did not show any prediction in the HT group. In summary, this study suggested that coexistent HT had insignificant protective effect on LNM and prognosis in PTMC, which was inconsistent with prior studies. Further studies aiming to determine novel predictors are recommended in PTMC patients with coexistent HT.

Keywords

Papillary thyroid microcarcinoma Hashimoto’s thyroiditis Lymph node metastasis Prognosis 

Notes

Acknowledgments

This research is supported by grants from the Key Project of Science and Technology Commission of Shanghai Municipality (11DJ1400200).

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Ning Qu
    • 1
  • Ling Zhang
    • 1
  • Dao-zhe Lin
    • 2
  • Qing-hai Ji
    • 1
    Email author
  • Yong-xue Zhu
    • 1
  • Yu Wang
    • 1
  1. 1.Department of Head and Neck Surgery, Fudan University Shanghai Cancer CenterDepartment of Oncology, Shanghai Medical College, Fudan UniversityShanghaiChina
  2. 2.Department of OncologyThe Third Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina

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