Tumor Biology

, Volume 37, Issue 5, pp 5991–5997 | Cite as

High expression of FOXR2 in breast cancer correlates with poor prognosis

  • Haiping Song
  • Wenshan He
  • Xiaoqing Huang
  • Huiqiong Zhang
  • Tao HuangEmail author
Original Article


Forkhead box protein R2 (FOXR2) is associated with human central nervous system neoplasms. However, the expression level of FOXR2 in breast cancer specimens remains largely unknown. To identify whether FOXR2 can serve as a biomarker for the diagnosis and prognosis of breast cancer, real-time PCR and immunohistochemistry (IHC) staining were utilized to detect the expression of FOXR2. The messenger RNA (mRNA) and protein levels of FOXR2 in breast cancer samples were novelty higher compared to non-tumorous breast tissues. IHC results revealed FOXR2 expression was significantly correlated to classifications tumor size (p = 0.007) and Ki-67 (p = 0.019). The patients with high expression of FOXR2 had a significantly poor prognosis compared to those of low expression (p = 0.003), especially in the patients with tumor size ≥2 cm (p = 0.006) and lymph node metastasis status (p = 0.004). Furthermore, multivariate analysis indicated that FOXR2 expression was an independent prognostic factor for breast cancer patients (p = 0.035). This study first identifies that FOXR2 may be an important molecular marker for diagnosis and prognosis of breast cancer.


FOXR2 Breast cancer Prognostic biomarker Immunohistochemistry 


Compliance with Ethical Standards

Conflicts of interest

The authors declare that they have no competing interests.


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Haiping Song
    • 1
  • Wenshan He
    • 1
  • Xiaoqing Huang
    • 1
  • Huiqiong Zhang
    • 1
  • Tao Huang
    • 1
    • 2
    Email author
  1. 1.Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of Breast and thyroid SurgeryUnion HospitalWuhanChina

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