Tumor Biology

, Volume 37, Issue 5, pp 6191–6196 | Cite as

Association between interleukin 8 −251 A/T and +781 C/T polymorphisms and osteosarcoma risk in Chinese population: a case–control study

  • Yang Chen
  • Yang Yang
  • Song Liu
  • Shaowen Zhu
  • Hongfeng JiangEmail author
  • Jinmin DingEmail author
Original Article


Interleukin-8 (IL-8) is an angiogenic chemokine that plays a potent role in both development and progression of many human malignancies. However, there are no data about the role of IL-8 polymorphism in development of osteosarcoma. A hospital-based case–control study was conducted among 190 patients with osteosarcoma and 190 healthy controls to investigate the possible association between the IL-8 −251 A/T and +781 C/T polymorphisms, respectively, and the risk of osteosarcoma. Significant differences of genotype distribution were observed between osteosarcoma cases and controls at the IL-8 −251T/A genotypes. Compared with the IL-8 −251T/A homozygote TT, the heterozygous TA genotype was associated with significantly increased risk for osteosarcoma (odds ratio (OR) = 2.16, 95 % confidence interval (CI) = (1.38–4.52), P = 0.021); the AA genotype was associated with increased risk for osteosarcoma (OR = 1.94, 95 % CI = 1.31–3.83, P = 0.018). TA and AA combined variants were associated with increased risk for osteosarcoma compared with the TT genotype (OR = 1.72, 95 % CI = 1.45–4.41, P = 0.023). Moreover, the genotype AA of IL-8 −251T/A carried a higher risk of osteosarcoma metastasis and later Enneking stages, compared with the TT genotype. However, the genotype and allele frequencies of IL-8 +781 C/T polymorphisms in osteosarcoma patients were not significantly different from controls. Our results showed that the IL-8 −251 A/T genotype was associated with increased risk for development and metastasis of osteosarcoma in Chinese Han population.


IL-8 Osteosarcoma Single-nucleotide polymorphism Susceptibility 


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Department of Orthopaedics InstituteTianjin HospitalTianjinChina
  2. 2.Department of OrthopaedicsThe Third Affiliated Hospital of Hebei Medical UniversityShijiazhuangChina
  3. 3.Department of OncologyPeking University Cancer HospitalBeijingChina

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