Tumor Biology

, Volume 37, Issue 12, pp 15575–15581 | Cite as

RETRACTED ARTICLE: MiR-429 regulates gastric cancer cell invasiveness through ZEB proteins

Original Article


MicroRNAs (miRNAs) play an essential role in the tumorigenesis of gastric carcinoma (GC). MiR-429 has been recently reported to inhibit GC growth; however, whether miR-429 may also regulate the invasion of GC cells is unknown. Here, we showed that miR-429 levels were significantly decreased and ZEB1 and ZEB2 levels were significantly increased in GC specimens, compared to the paired adjacent non-tumor gastric tissue. Moreover, the levels of miR-429 and ZEB1 or ZEB2 inversely correlated in GC specimens. Bioinformatics analyses showed that miR-429 targeted the 3′-untranslated region of both ZEB1 and ZEB2 mRNA to inhibit their translation, which was confirmed by luciferase reporter assay. Overexpression of miR-429 inhibited ZEB1/2-mediated cell invasiveness, while depletion of miR-429 augmented it. Together, our data suggest that miR-429 suppression in GC promotes ZEB1/2-mediated cancer cell invasion.


Gastric carcinoma (GC) ZEB1 ZEB2 miR-429 


Compliance with ethical standards

Prior patient’s consents and approval from the Institutional Research Ethics Committee of the Bethune International Peace Hospital were obtained for this study.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Department of General SurgeryThe Bethune International Peace HospitalShijiazhuangChina
  2. 2.Department of PathologyThe Bethune International Peace HospitalShijiazhuangChina

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