Tumor Biology

, Volume 37, Issue 12, pp 15575–15581 | Cite as

RETRACTED ARTICLE: MiR-429 regulates gastric cancer cell invasiveness through ZEB proteins

Original Article

Abstract

MicroRNAs (miRNAs) play an essential role in the tumorigenesis of gastric carcinoma (GC). MiR-429 has been recently reported to inhibit GC growth; however, whether miR-429 may also regulate the invasion of GC cells is unknown. Here, we showed that miR-429 levels were significantly decreased and ZEB1 and ZEB2 levels were significantly increased in GC specimens, compared to the paired adjacent non-tumor gastric tissue. Moreover, the levels of miR-429 and ZEB1 or ZEB2 inversely correlated in GC specimens. Bioinformatics analyses showed that miR-429 targeted the 3′-untranslated region of both ZEB1 and ZEB2 mRNA to inhibit their translation, which was confirmed by luciferase reporter assay. Overexpression of miR-429 inhibited ZEB1/2-mediated cell invasiveness, while depletion of miR-429 augmented it. Together, our data suggest that miR-429 suppression in GC promotes ZEB1/2-mediated cancer cell invasion.

Keywords

Gastric carcinoma (GC) ZEB1 ZEB2 miR-429 

Notes

Compliance with ethical standards

Prior patient’s consents and approval from the Institutional Research Ethics Committee of the Bethune International Peace Hospital were obtained for this study.

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Department of General SurgeryThe Bethune International Peace HospitalShijiazhuangChina
  2. 2.Department of PathologyThe Bethune International Peace HospitalShijiazhuangChina

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