Tumor Biology

, Volume 36, Issue 8, pp 6497–6505 | Cite as

Down-regulation of miR-489 contributes into NSCLC cell invasion through targeting SUZ12

  • Zongtao Xie
  • Liming Cai
  • Runsheng Li
  • Jinyu Zheng
  • Hongyan Wu
  • Xiaoqi Yang
  • Hu Li
  • Zhiqiang WangEmail author
Research Article


microRNAs are small, non-coding RNAs that contribute into various biological processes during cancer progression. However, the potential role of miR-489 in the development of Non-Small Cell Lung Cancer (NSCLC) is not demonstrated. In present study, miR-489 was down-regulated both in tumor tissues and cells. Inhibition of miR-489 promoted cells invasion by using an invasion assay. Furthermore, miR-489 could regulate SUZ12 as shown by luciferase reporter and Western blot assays. Aberrant miR-489 expression could regulate the molecular changes (E-cadherin, N-cadherin, and Vimentin) of epithelial mesenchymal transition (EMT). In conclusion, our study revealed that miR-489 may play an essential role in the progression of NSCLC.


miR-489 SUZ12 Invasion EMT NSCLC 



We thank our mentor in our lab for critical reading of the manuscript.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  • Zongtao Xie
    • 1
  • Liming Cai
    • 2
  • Runsheng Li
    • 2
  • Jinyu Zheng
    • 3
  • Hongyan Wu
    • 3
  • Xiaoqi Yang
    • 4
  • Hu Li
    • 5
  • Zhiqiang Wang
    • 1
    Email author
  1. 1.Department of Thoracic and Cardiovascular Surgery, Affiliated Hospital of Jiangnan UniversityThe Forth People’s Hospital of Wuxi CityWuxiChina
  2. 2.Department of Respiratory Medicine, Affiliated Hospital of Jiangnan UniversityThe Forth People’s Hospital of Wuxi CityWuxiChina
  3. 3.Department of Pathology, Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjingChina
  4. 4.Department of Orthopedics, Affiliated Hospital of Jiangnan UniversityThe Forth People’s Hospital of Wuxi CityWuxiChina
  5. 5.Department of Plastic Surgery, Affiliated Hospital of Jiangnan UniversityThe Forth People’s Hospital of Wuxi CityWuxiChina

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