Tumor Biology

, Volume 36, Issue 6, pp 4519–4523 | Cite as

RETRACTED ARTICLE: Insulin-like growth factor 1 promotes growth of gastric cancer by inhibiting foxo1 nuclear retention

  • Shuangling Li
  • Xiaofei Lei
  • Jianna Zhang
  • Hongli Yang
  • Jiyong Liu
  • Changqing Xu
Research Article


Gastric cancer (GC) is the fourth most common malignant human cancer. So far, the molecular mechanisms underlying the tumorigenesis of GC are not completely understood. Here, we reported significantly higher levels of serum insulin-like growth factor (IGF)-1 in GC patients and significantly higher levels of phosphorylated IGF-1 receptor (IGF-1R) in the GC specimen. Moreover, IGF-1 induced phosphorylation of IGF-1R and then phosphorylation of its downstream factor Akt in the GC cells. Further, IGF-1/Akt-induced forkhead box protein O1 (FoxO1) nuclear exclusion, but not IGF-1/Akt-induced mTOR phosphorylation, was essential for the augment in GC cell growth. Together, IGF-1/Akt/FoxO1 regulatory machinery appears to be a previously unappreciated signaling axis involved in the carcinogenesis of GC.


Gastric cancer Insulin-like growth factor 1 (IGF-1) Akt mTOR FoxO1 Cancer growth 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2015

Authors and Affiliations

  1. 1.Department of Gastroenterology, Shandong Provincial Qianfoshan HospitalShandong UniversityJinanChina
  2. 2.Shandong University School of MedicineJinanChina
  3. 3.Department of GastroenterologyProvincial Hospital Affiliated to Shandong UniversityJinanChina

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