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Tumor Biology

, Volume 35, Issue 12, pp 12103–12107 | Cite as

miR-141 suppresses the growth and metastasis of HCC cells by targeting E2F3

  • Jun Xue
  • Yan-Feng Niu
  • Jing Huang
  • Gang Peng
  • Li-xia Wang
  • Yu-Hui Yang
  • Yun-Qiao LiEmail author
Research Article

Abstract

MicroRNAs (miRNAs) function as essential post-transcriptional modulators of gene expression involved in a wide range of physiologic and pathologic states, including cancer. Numerous miRNAs have been deregulated in hepatocellular carcinoma (HCC). Here, we investigated the role of miR-141 in HCC. Decreased expression of miR-141 was observed in both HCC tissues and cell lines. Ectopic overexpression of miR-141 reduced proliferation, migration, and invasion of HCC cells. E2F transcription factor 3 (E2F3) was confirmed to be a target of miR-141 in HCC cells. Moreover, restoration of E2F3 significantly reversed the tumor suppressive effects of miR-141. Our results suggest a critical role of miR-141 in suppressing metastasis of HCC cells by targeting E2F3.

Keywords

HCC miR-141 E2F3 Proliferation Migration Invasion 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Jun Xue
    • 1
  • Yan-Feng Niu
    • 2
  • Jing Huang
    • 1
  • Gang Peng
    • 1
  • Li-xia Wang
    • 3
  • Yu-Hui Yang
    • 1
  • Yun-Qiao Li
    • 4
    Email author
  1. 1.Cancer Center, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  2. 2.Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  3. 3.Department of Radiology, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina
  4. 4.Department of Geriatrics, Union Hospital, Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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