Tumor Biology

, Volume 35, Issue 12, pp 11985–11994 | Cite as

20(s)-ginsenoside Rg3 promotes apoptosis in human ovarian cancer HO-8910 cells through PI3K/Akt and XIAP pathways

Research Article

Abstract

Ovarian cancer is a serious tumor which represents a great threat to women’s health. Recently, researchers had found that 20(s)-ginsenoside Rg3 could inhibit growth of several cancer cell lines; however, the mechanism is not fully understood so far. In the present study, we found that 20(s)-ginsenoside Rg3 reduced cell viability and induced apoptosis in a dose- and time-dependent manner in the human ovarian cancer cells HO-8910. The induction of apoptosis was accompanied by downregulation of phosphatidylinositol 3-kinase (PI3K)/Akt family proteins and inhibitor of apoptosis protein (IAP) family proteins. 20(s)-ginsenoside Rg3 treatment resulted in activation of caspase-3 and -9, which may partly explain the anti-cancer activity of 20(s)-ginsenoside Rg3. Taken together, our study for the first time suggests that 20(s)-ginsenoside Rg3 is able to enhance apoptosis of HO-8910 cells, at least in part, through downregulation of PI3K/Akt and IAP family proteins. Moreover, the triggering of caspase-3 and -9 activation mediated apoptotic induction. Our data indicate that 20(s)-ginsenoside Rg3 is an effective apoptosis-inducing natural compound in ovarian cancer cells and may have a role in future therapies for ovarian cancer.

Keywords

Ginsenoside Rg3 HO-8910 Apoptosis Caspase 

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Jia-He Wang
    • 1
  • Jian-Fei Nao
    • 2
  • Meng Zhang
    • 1
  • Ping He
    • 1
  1. 1.Department of GeriatricsShengjing Hospital of China Medical UniversityShenyangPeople’s Republic of China
  2. 2.Department of NeurologyShengjing Hospital of China Medical UniversityShenyangPeople’s Republic of China

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