Tumor Biology

, Volume 35, Issue 10, pp 10111–10119 | Cite as

RETRACTED ARTICLE: Association between APE1 T1349G polymorphism and prostate cancer risk: evidence from a meta-analysis

Research Article

Abstract

APE1 T1349G polymorphism was considered to be associated with risk of cancer, but studies on the association between APE1 T1349G polymorphism and risk of prostate cancer remained inconclusive. A meta-analysis of published studies was performed to precisely assess the association between APE1 Asp148Glu polymorphism and prostate cancer risk. PubMed, Embase, and Wanfang databases were searched for published case–control studies investigating the association between APE1 T1349G polymorphism and prostate cancer risk. Odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were used to assess the strength of the association. Overall, seven studies with a total of 3,063 individuals were finally included into the meta-analysis. The heterogeneity analysis did not find obvious heterogeneity among those included studies. Meta-analysis of total seven studies did not find an obvious association between APE1 T1349G polymorphism and prostate cancer risk (G vs T OR (95 % CI) = 1.11 (0.99–1.24); GG vs TT OR (95 % CI) = 1.25 (0.96–1.62); TG vs TT OR (95 % CI) = 1.11 (0.95–1.30); GG/TG vs T OR (95 % CI) = 1.13 (0.97–1.32); GG vs TT/TG OR (95 % CI) = 1.16 (0.91–1.48)). Subgroup analyses by ethnicity showed that APE1 T1349G polymorphism was associated with increased risk of prostate cancer in Caucasians (G vs T OR (95 % CI) = 1.26 (1.02–1.56), P = 0.033; TG vs TT OR (95 % CI) = 1.44 (1.06–1.94), P = 0.019; GG/TG vs T OR (95 % CI) = 1.45 (1.08–1.94), P = 0.013). The meta-analysis suggests that APE1 T1349G polymorphism is associated with increased risk of prostate cancer, especially in Caucasians. More studies are needed to further identify the obvious association above.

Keywords

APE1 Polymorphism Prostate cancer Meta-analysis 

Notes

Acknowledgments

This study was funded by the Science Foundation of China (Grant No. 81101926), and the Science Foundation of Liaoning Province (Grant No. 2013020195 and Grant No. 2013020221).

Conflicts of interest

None.

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Xin Li
    • 1
  • Geng Zhang
    • 2
  • Yong-Jun Huai
    • 3
  • Zhi-Qiang Cao
    • 1
  1. 1.Department of Urinary SurgeryGeneral Hospital of Shenyang Military RegionShenyangChina
  2. 2.Department of Urinary SurgeryXijing Hospital, Fourth Military Medical UniversityXi’anChina
  3. 3.Department of PneumologyGeneral Hospital of Shenyang Military RegionShenyangChina

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