Tumor Biology

, Volume 35, Issue 10, pp 10111–10119 | Cite as

RETRACTED ARTICLE: Association between APE1 T1349G polymorphism and prostate cancer risk: evidence from a meta-analysis

  • Xin Li
  • Geng Zhang
  • Yong-Jun Huai
  • Zhi-Qiang Cao
Research Article


APE1 T1349G polymorphism was considered to be associated with risk of cancer, but studies on the association between APE1 T1349G polymorphism and risk of prostate cancer remained inconclusive. A meta-analysis of published studies was performed to precisely assess the association between APE1 Asp148Glu polymorphism and prostate cancer risk. PubMed, Embase, and Wanfang databases were searched for published case–control studies investigating the association between APE1 T1349G polymorphism and prostate cancer risk. Odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were used to assess the strength of the association. Overall, seven studies with a total of 3,063 individuals were finally included into the meta-analysis. The heterogeneity analysis did not find obvious heterogeneity among those included studies. Meta-analysis of total seven studies did not find an obvious association between APE1 T1349G polymorphism and prostate cancer risk (G vs T OR (95 % CI) = 1.11 (0.99–1.24); GG vs TT OR (95 % CI) = 1.25 (0.96–1.62); TG vs TT OR (95 % CI) = 1.11 (0.95–1.30); GG/TG vs T OR (95 % CI) = 1.13 (0.97–1.32); GG vs TT/TG OR (95 % CI) = 1.16 (0.91–1.48)). Subgroup analyses by ethnicity showed that APE1 T1349G polymorphism was associated with increased risk of prostate cancer in Caucasians (G vs T OR (95 % CI) = 1.26 (1.02–1.56), P = 0.033; TG vs TT OR (95 % CI) = 1.44 (1.06–1.94), P = 0.019; GG/TG vs T OR (95 % CI) = 1.45 (1.08–1.94), P = 0.013). The meta-analysis suggests that APE1 T1349G polymorphism is associated with increased risk of prostate cancer, especially in Caucasians. More studies are needed to further identify the obvious association above.


APE1 Polymorphism Prostate cancer Meta-analysis 



This study was funded by the Science Foundation of China (Grant No. 81101926), and the Science Foundation of Liaoning Province (Grant No. 2013020195 and Grant No. 2013020221).

Conflicts of interest



  1. 1.
    Damber JE, Aus G. Prostate cancer. Lancet. 2008;371:1710–21.CrossRefPubMedGoogle Scholar
  2. 2.
    Schroder FH, Hugosson J, Roobol MJ, Tammela TL, Ciatto S, Nelen V, et al. Prostate-cancer mortality at 11 years of follow-up. N Engl J Med. 2012;366:981–90.CrossRefPubMedGoogle Scholar
  3. 3.
    Rodriguez C, Patel AV, Mondul AM, Jacobs EJ, Thun MJ, Calle EE. Diabetes and risk of prostate cancer in a prospective cohort of US men. Am J Epidemiol. 2005;161:147–52.CrossRefPubMedGoogle Scholar
  4. 4.
    Amankwah EK, Sellers TA, Park JY. Gene variants in the angiogenesis pathway and prostate cancer. Carcinogenesis. 2012;33:1259–69.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Gao R, Price DK, Dahut WL, Reed E, Figg WD. Genetic polymorphisms in XRCC1 associated with radiation therapy in prostate cancer. Cancer Biol Ther. 2010;10:13–8.CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Agalliu I, Kwon EM, Salinas CA, Koopmeiners JS, Ostrander EA, Stanford JL. Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study. Cancer Causes Control. 2010;21:289–300.CrossRefPubMedGoogle Scholar
  7. 7.
    Kuasne H, Rodrigues IS, Losi-Guembarovski R, Reis MB, Fuganti PE, Gregorio EP, et al. Base excision repair genes XRCC1 and APEX1 and the risk for prostate cancer. Mol Biol Rep. 2011;38:1585–91.CrossRefPubMedGoogle Scholar
  8. 8.
    Jiang J, Zhang X, Yang H, Wang W. Polymorphisms of DNA repair genes: ADPRT, XRCC1, and XPD and cancer risk in genetic epidemiology. Methods Mol Biol. 2009;471:305–33.CrossRefPubMedGoogle Scholar
  9. 9.
    Karahalil B, Bohr VA, Wilson 3rd DM. Impact of DNA polymorphisms in key DNA base excision repair proteins on cancer risk. Hum Exp Toxicol. 2012;31:981–1005.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    Jing B, Wang J, Chang WL, Li B, Chen J, Niu YJ. Association of the polymorphism of APE1 gene with the risk of prostate cancer in chinese han population. Clin Lab. 2013;59:163–8.CrossRefPubMedGoogle Scholar
  11. 11.
    Zienolddiny S, Campa D, Lind H, Ryberg D, Skaug V, Stangeland L, et al. Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. Carcinogenesis. 2006;27:560–7.CrossRefPubMedGoogle Scholar
  12. 12.
    Das A, Wiederhold L, Leppard JB, Kedar P, Prasad R, Wang H, et al. NEIL2-initiated, APE-independent repair of oxidized bases in DNA: evidence for a repair complex in human cells. DNA Repair (Amst). 2006;5:1439–48.CrossRefPubMedCentralGoogle Scholar
  13. 13.
    Chen L, Ambrosone CB, Lee J, Sellers TA, Pow-Sang J, Park JY. Association between polymorphisms in the DNA repair genes XRCC1 and APE1, and the risk of prostate cancer in white and black americans. J Urol. 2006;175:108–12. discussion 12.CrossRefPubMedGoogle Scholar
  14. 14.
    Lavender NA, Komolafe OO, Benford M, Brock G, Moore JH, Vancleave TT, et al. No association between variant DNA repair genes and prostate cancer risk among men of african descent. Prostate. 2010;70:113–9.PubMedPubMedCentralGoogle Scholar
  15. 15.
    Mandal RK, Gangwar R, Kapoor R, Mittal RD. Polymorphisms in base-excision & nucleotide-excision repair genes & prostate cancer risk in north indian population. Indian J Med Res. 2012;135:64–71.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Mittal RD, Mandal RK, Gangwar R. Base excision repair pathway genes polymorphism in prostate and bladder cancer risk in North Indian population. Mech Ageing Dev. 2012;133:127–32.CrossRefPubMedGoogle Scholar
  17. 17.
    Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.CrossRefPubMedPubMedCentralGoogle Scholar
  18. 18.
    DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.CrossRefPubMedGoogle Scholar
  19. 19.
    Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.PubMedGoogle Scholar
  20. 20.
    Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34.CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Hung RJ, Hall J, Brennan P, Boffetta P. Genetic polymorphisms in the base excision repair pathway and cancer risk: a huge review. Am J Epidemiol. 2005;162:925–42.CrossRefPubMedGoogle Scholar
  22. 22.
    Gu D, Wang M, Zhang Z, Chen J. The DNA repair gene APE1 T1349G polymorphism and cancer risk: a meta-analysis of 27 case-control studies. Mutagenesis. 2009;24:507–12.CrossRefPubMedGoogle Scholar
  23. 23.
    Zhou B, Shan H, Su Y, Xia K, Shao X, Mao W, et al. The association of APE1–656 T > G and 1349 T > G polymorphisms and cancer risk: a meta-analysis based on 37 case-control studies. BMC Cancer. 2011;11:521.CrossRefPubMedPubMedCentralGoogle Scholar
  24. 24.
    Liu C, Yin Q, Li L, Zhuang YZ, Zu X, Wang Y. APE1 Asp148Glu gene polymorphism and bladder cancer risk: a meta-analysis. Mol Biol Rep. 2013;40:171–6.CrossRefPubMedGoogle Scholar
  25. 25.
    25 Jin F, Qian C, Qing Y, Zhang Z, Wang G, Shan J, et al. Genetic polymorphism of APE1 rs1130409 can contribute to the risk of lung cancer. Tumour Biol. 2014 Apr 6. [Epub ahead of print].Google Scholar
  26. 26.
    Wang YM, Liu ZW, Guo JB, Wang XF, Zhao XX, Zheng X. ESR1 gene polymorphisms and prostate cancer risk: a HuGE review and meta-analysis. PLoS One. 2013;8:e66999.CrossRefPubMedPubMedCentralGoogle Scholar
  27. 27.
    Zhang H, Li L, Xu Y. CYP1B1 polymorphisms and susceptibility to prostate cancer: a meta-analysis. PLoS One. 2013;8:e68634.CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    Zou YF, Tao JH, Ye QL, Pan HF, Pan FM, Su H, et al. Association of xpc gene polymorphisms with susceptibility to prostate cancer: evidence from 3,936 subjects. Genet Test Mol Biomarkers. 2013;17:926–31.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Xin Li
    • 1
  • Geng Zhang
    • 2
  • Yong-Jun Huai
    • 3
  • Zhi-Qiang Cao
    • 1
  1. 1.Department of Urinary SurgeryGeneral Hospital of Shenyang Military RegionShenyangChina
  2. 2.Department of Urinary SurgeryXijing Hospital, Fourth Military Medical UniversityXi’anChina
  3. 3.Department of PneumologyGeneral Hospital of Shenyang Military RegionShenyangChina

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