Tumor Biology

, Volume 35, Issue 9, pp 8633–8638 | Cite as

RETRACTED ARTICLE: FBXL5 targets cortactin for ubiquitination-mediated destruction to regulate gastric cancer cell migration

Research Article


Cortactin, an actin-interacting protein, is implicated in cytoskeletal architecture and often amplified in several types of cancer including gastric adenocarcinomas. Downregulation of cortactin decreases cell migration and invasion. However, how to regulate cortactin in gastric cancer remains largely unknown. Here, we report that FBXL5 interacts with and targets cortactin for ubiquitylation and subsequent proteasomal degradation. Furthermore, we showed that FBXL5-induced cortactin degradation is mediated by extracellular regulated signal kinase (ERK). Serine phosphorylation sites mutant, cortactinS405A/S418A, prevent FBXL5-induced cortactin degradation. Moreover, CortactinS405A/S418A exhibited stronger effects in promoting gastric cancer cell migration when compared to wild-type cortactin. Taken together, our data suggested a novel molecular mechanism for the negative regulation of cortactin by FBXL5 in gastric cancer cells migration.


FBXL5 Cortactin Ubiquitylation Gastric cancer 


Conflict of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  1. 1.Department of General SurgeryThe First People’s Hospital Affiliated to Shanghai JiaoTong UniversityShanghaiChina
  2. 2.Department of oncologyThe First People’s Hospital Affiliated to Shanghai JiaoTong UniversityShanghaiChina
  3. 3.Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghaiChina

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