Tumor Biology

, Volume 35, Issue 11, pp 10731–10736 | Cite as

miR-24 promotes the proliferation and invasion of HCC cells by targeting SOX7

  • Ying Ma
  • Xing-guo SheEmail author
  • Ying-zi Ming
  • Qi-quan Wan
Research Article


Accumulating evidence shows that microRNAs (miRNAs) are involved in the development and progression of multiple tumors, including hepatocellular carcinoma (HCC). Recent studies have found that miR-24 acts as an oncogene in several tumors; however, the function of miR-24 in HCC remains unclear. In this study, we found that miR-24 was increased in HCC tissues and cell lines. Inhibition of miR-24 by inhibitor significantly suppressed HCC cells proliferation, migration, and invasion. Furthermore, the sex-determining region Y (SRY)-box 7 (SOX7), a putative tumor suppressor, was found to be a target of miR-24 in HCC cells. Forced expression of SOX7 substantially attenuated the oncogenic effects of miR-24. Those results strongly suggest that miR-24 plays important role in HCC development partially by targeting SOX7.


Hepatocellular carcinoma miR-24 SOX7 Proliferation Migration Invasion 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Ying Ma
    • 1
  • Xing-guo She
    • 1
    Email author
  • Ying-zi Ming
    • 1
  • Qi-quan Wan
    • 1
  1. 1.Departments of Transplant Surgery, the Third Affiliated HospitalCentral South UniversityHunanChina

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