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Tumor Biology

, Volume 35, Issue 11, pp 10731–10736 | Cite as

miR-24 promotes the proliferation and invasion of HCC cells by targeting SOX7

  • Ying Ma
  • Xing-guo She
  • Ying-zi Ming
  • Qi-quan Wan
Research Article

Abstract

Accumulating evidence shows that microRNAs (miRNAs) are involved in the development and progression of multiple tumors, including hepatocellular carcinoma (HCC). Recent studies have found that miR-24 acts as an oncogene in several tumors; however, the function of miR-24 in HCC remains unclear. In this study, we found that miR-24 was increased in HCC tissues and cell lines. Inhibition of miR-24 by inhibitor significantly suppressed HCC cells proliferation, migration, and invasion. Furthermore, the sex-determining region Y (SRY)-box 7 (SOX7), a putative tumor suppressor, was found to be a target of miR-24 in HCC cells. Forced expression of SOX7 substantially attenuated the oncogenic effects of miR-24. Those results strongly suggest that miR-24 plays important role in HCC development partially by targeting SOX7.

Keywords

Hepatocellular carcinoma miR-24 SOX7 Proliferation Migration Invasion 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Ying Ma
    • 1
  • Xing-guo She
    • 1
  • Ying-zi Ming
    • 1
  • Qi-quan Wan
    • 1
  1. 1.Departments of Transplant Surgery, the Third Affiliated HospitalCentral South UniversityHunanChina

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