Tumor Biology

, Volume 35, Issue 7, pp 7073–7077 | Cite as

Association of periodontal disease with oral cancer: a meta-analysis

  • Qi-Wei Yao
  • Dong-Sheng Zhou
  • Hong-Juan Peng
  • Ping JiEmail author
  • De-Sheng Liu
Research Article


The objective is to evaluate the association of periodontal disease with the risk of oral cancer. Literature retrieval, selection and assessment, data extraction, and meta-analyses were performed according to the RevMan 5.0 guidelines. In the meta-analysis, we utilized random-effect model to pool the odds ratio (OR) according to the test of heterogeneity. A total of five eligible studies included 1,191 oral cancer patients and 1,992 healthy control subjects were analyzed. By meta-analysis, we found a significant association of periodontal disease with oral cancer [OR = 3.53, 95 % CI (1.52–8.23); P = 0.003]. Patients with periodontal disease have increased susceptibility to oral cancer.


Periodontal disease Oral cancer Case-control study Cohort study 


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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Qi-Wei Yao
    • 1
    • 2
    • 3
  • Dong-Sheng Zhou
    • 4
  • Hong-Juan Peng
    • 5
  • Ping Ji
    • 1
    • 3
    Email author
  • De-Sheng Liu
    • 6
  1. 1.School of StomatologyShandong UniversityJinanPeople’s Republic of China
  2. 2.Department of StomatologyQianfoshan Hospital Affiliated to Shandong UniversityJinanPeople’s Republic of China
  3. 3.Shandong Provincial Key Laboratory of Oral BiomedicineJinanPeople’s Republic of China
  4. 4.Department of StomatologyHeze Municipal HospitalHezePeople’s Republic of China
  5. 5.Shandong Medical Imaging InstituteJinanPeople’s Republic of China
  6. 6.Department of StomatologyPeople’s Hospital of RizhaoRizhaoPeople’s Republic of China

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