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Tumor Biology

, Volume 35, Issue 7, pp 6665–6671 | Cite as

Genetic polymorphism of APE1 rs1130409 can contribute to the risk of lung cancer

  • Feng Jin
  • Chengyuan Qian
  • Yi Qing
  • Zhimin Zhang
  • Ge Wang
  • Jinlu Shan
  • Nan Dai
  • Zheng Li
  • Dong WangEmail author
Research Article

Abstract

Accumulative evidence suggests that polymorphism in the APE1 gene may have association with the etiology of lung cancer by modulating DNA repair capacity. Many studies have evaluated the association with great discrepancies in the results. The present meta-analysis was undertaken to clarify the effects of this polymorphism on lung cancer. A meta-analysis of 15 studies with 4,932 lung cancer patients and 6,555 cancer-free controls was conducted to evaluate the strength of the association using odds ratios (ORs) with 95 % confidence intervals (CIs). Overall, no significant association was found between APE1 polymorphism and lung cancer risk. We also did not observe any statistical evidence of modified lung cancer risk either in smokes or in nonsmokers. In the stratified analysis by ethnicity, however, it was found that the Glu/Clu genotype carriers had 1.16-fold higher risk of suffering lung cancer compared with the carriers of Arg/Glu + Arg/Arg genotypes in Asian population (OR = 1.16, 95 % CI = 1.01-1.32, P = 0.242). This meta-analysis provides statistical evidence for a potential association between APE1 polymorphism and an increased risk of lung cancer in Asian population.

Key words

APE1 Polymorphism Lung cancer Meta-analysis 

Notes

Acknowledgments

Financial support was provided by China NSFC: The effect and mechanism of APE1 in angiogenesis after radiotherapy (No. 30901747).

Conflicts of interest

None.

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Feng Jin
    • 1
  • Chengyuan Qian
    • 1
  • Yi Qing
    • 1
  • Zhimin Zhang
    • 1
  • Ge Wang
    • 1
  • Jinlu Shan
    • 1
  • Nan Dai
    • 1
  • Zheng Li
    • 1
  • Dong Wang
    • 1
    Email author
  1. 1.Cancer Center, Research Institute of Surgery and Daping HospitalThird Military Medical UniversityChongqingChina

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