Tea consumption and leukemia risk: a meta-analysis
- 282 Downloads
Epidemiologic findings concerning the association between tea consumption and leukemia risk yielded mixed results. We aimed to investigate the association by performing a meta-analysis of all available studies. One cohort studies and six case-control studies with 1,019 cases were identified using PubMed, Web of Science, and EMBASE. We computed summary relative risks (RRs) and 95 % confidence intervals (CIs) using random effect model applied to the relative risk associated with ever, moderate, or highest drinkers vs. non/lowest drinkers. Subgroup analyses were performed based on country (China and USA). Compared with non/lowest drinkers, the combined RR for ever drinkers was 0.76 (95 % CI = 0.65–0.89). In subgroup analyses, significant inverse associations were found for both China and USA studies. The summary RR was 0.57 (95 % CI = 0.41–0.78) for highest drinkers. Same results were only found in China studies. No significant associations were found for moderate drinkers in overall analysis or in subgroup analyses. There was some evidence of publication bias. In conclusion, this meta-analysis suggests a significant inverse association of high tea consumption and leukemia risk. Results should be interpreted cautiously given the potential publication bias.
KeywordsCancer risk Diet Epidemiology
This study was supported by the National Natural Science Foundation of China (81272470).
- 1.American Cancer Society. Global cancer facts & figures 2nd edition. Atlanta: American cancer society; 2011.Google Scholar
- 2.Howlader N, Noone A, Krapcho M, Garshell J, Neyman N, Altekruse S, Kosary CL YM, Ruhl J, Tatalovich Z, Cho H, Mariotto A, Lewis D, Chen H, Feuer E, Cronin Ke: Seer cancer statistics review, 1975-2010, National Cancer Institute. Bethesda, md, http://seer.Cancer.Gov/csr/1975_2010/, based on November 2012 seer data submission, posted to the seer web site, 2013
- 16.Wells G, Shea B, O’Connell D, Robertson J, Peterson J, Welch V, Losos M, Tugwell P: The Newcastle-Ottawa scale (nos) for assessing the quality of nonrandomised studies in meta-analyses. http://www.ohri.ca/programs/clinical_epidemiology/oxford_web.ppt 2010
- 32.Britschgi A, Simon HU, Tobler A, Fey MF, Tschan MP. Epigallocatechin-3-gallate induces cell death in acute myeloid leukaemia cells and supports all-trans retinoic acid-induced neutrophil differentiation via death-associated protein kinase 2. Br J Haematol. 2010;149:55–64.CrossRefPubMedGoogle Scholar
- 36.Lopez-Lazaro M, Calderon-Montano JM, Burgos-Moron E, Austin CA. Green tea constituents (-)-epigallocatechin-3-gallate (egcg) and gallic acid induce topoisomerase i- and topoisomerase ii-DNA complexes in cells mediated by pyrogallol-induced hydrogen peroxide. Mutagenesis. 2011;26:489–98.CrossRefPubMedGoogle Scholar