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Tumor Biology

, Volume 35, Issue 5, pp 5053–5053 | Cite as

Letter regarding Wen X.Y. et al. entitled “Matrix metalloproteinase 2 expression and survival of patients with osteosarcoma: a meta-analysis”

  • Hong-bin Guo
  • Tao Xiao
Editorial

Dear Editor,

In a recent issue of Tumor Biology, Xiaoyang Wen and his workmates published an article [1] entitled “Matrix metalloproteinase 2 expression and survival of patients with osteosarcoma: a meta-analysis”. In this study, the investigators performed a meta-analysis to derive a precise estimate of the prognostic role of MMP2 expression in patients with osteosarcoma. The investigators concluded that osteosarcoma patients with high MMP2 expression have poorer prognosis compared with those with low MMP2 expression. However, we have several opinions that we would like to raise to the investigators.

Firstly, the investigators just searched three electronic databases (PubMed, EMBASE, and Wanfang databases). The small number of required papers would be an important limitation of the review. We hope that more electronic databases can be systematically searched. In the same time, the investigators had not focused specifically on the issue of the completeness of the search strategy report for databases. They just described the retrieval strategy by using the keywords such as, “osteosarcoma” or “osteosarcomas”, and “MMP2” or “matrix metalloproteinase-2”. We suggest that the investigators should provide us the details of the retrieval strategy and the flowchart of selection.

Secondly, in the results section, the investigators just provide us a forest plot to clarify the prognostic role of MMP2 expression in patients with osteosarcoma. Inexplicably, what dose the forest plot and the RR value mean. In our opinion, the investigators should clarify its prognostic role with forest plots of 5-year overall survival (OS) rate and 5-year disease free survival (DFS) rate.

Thirdly, the investigators included five cohort studies [2, 3, 4, 5, 6] including 297 patients with osteosarcoma. However, the investigators did not provide us any characteristics of these eligible studies. We suggest that the investigators should provide us its characteristics in tables to make us read the meta-analysis well.

Finally, the investigators did not follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). As a minor suggestion, adding PRISMA checklist some summery could make this manuscript better.

Moreover, more studies with larger sample size are needed to get a more precise estimate of the prognostic role of MMP2 expression in osteosarcoma.

References

  1. 1.
    Wen X, Liu H, Yu K, Liu Y. Matrix metalloproteinase 2 expression and survival of patients with osteosarcoma: a meta-analysis. Tumour Biol. 2013. doi: 10.1007/s13277-013-1116-1.Google Scholar
  2. 2.
    Uchibori M, Nishida Y, Nagasaka T, Yamada Y, Nakanishi K, Ishiguro N. Increased expression of membrane-type matrix metalloproteinase-1 is correlated with poor prognosis in patients with osteosarcoma. Int J Oncol. 2006;28:33–42.PubMedGoogle Scholar
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    Li W, Ye Z, Yang D, Tao H. The expression of vascular endothelial growth factor, matrix metalloproteinases 2,9 in osteosarcoma [article in Chinese]. Zhejiang Med J. 2006;28:691–4.Google Scholar
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    Kushlinsky NE, Solovyov YN, Babkina IV, Gershtein ES, Bulicheva IV. Matrix metalloproteinases 2,7, and tissue inhibitor of matrix metalloproteinase-1 in the sera of patients with bone tumors. Bull Exp Biol Med. 2010;149:233–5.CrossRefPubMedGoogle Scholar
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    Sun C, Zang Y, Yang L, Liu H, Li S. Association of malignant osteoblastoma prognosis with midkine, survivin and MMP-2 expression [article in Chinese]. Med Recapitulate. 2010;16:3833–4.Google Scholar
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    Xu J, Shi X, Wu S, Zhang X, Zhou Z. Expression and clinical significance of reck and MMP-2 in osteosarcoma [article in Chinese]. Chin Clin Oncol. 2010;15:222–5.Google Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  1. 1.Department of OrthopedicsThe Second Xiangya Hospital of Central South UniversityChangshaChina

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