Tumor Biology

, Volume 35, Issue 5, pp 4589–4597 | Cite as

RETRACTED ARTICLE: The prognosis and clinicopathology of CXCR4 in gastric cancer patients: a meta-analysis

  • Mingzhi Han
  • Shunzeng Lv
  • Ya Zhang
  • Ruiyang Yi
  • Bin Huang
  • Hanhui Fu
  • Ruixiang Bian
  • Xingang Li
Research Article

Abstract

The chemokine receptor 4 (CXCR4) has been widely investigated in diagnosis and prognosis of gastric cancer (GC). However, the impact of CXCR4 on GC patients remains controversial; Here, we conducted a meta-analysis to obtain the precise role of CXCR4 in GC prognosis and clinicopathology. Thirteen published studies with a total of 1,936 patients were included. Original data included the hazard ratio (HR) of overall survival (OS) and odds ratio (OR) in GC patients. We combined HR/OR with 95 % confidence interval (CI) to estimate the hazard. In this study, OS was significantly related to CXCR4 expression, with the HR 2.63 (95 % CI 1.69–4.09; p < 0.0001), and a significant correlation was also revealed between CXCR4 expression and stage (I + II, +) (OR 0.52, 95 % CI 0.32–0.83; p = 0.007), depth of invasion (T1/T2, +) (OR 0.44, 95 % CI 0.27–0.73; p = 0.001), lymph node metastasis (LN, +) (OR 2.30, 95 % CI 1.57–3.36; p < 0.0001), as well as vascular invasion (vas.inv, +) (OR 0.72, 95 % CI 0.53–0.98; p = 0.04). Heterogeneity was observed among the included studies with OS (I 2 = 51 %), stage (I 2 = 78 %), depth of invasion (I 2 = 74 %), lymph node metastasis (I 2 = 64 %), and histology differentiation (I 2 = 79 %). No publication bias was observed. In conclusion, this meta-analysis showed CXCR4 expression indicates poor prognosis in GC patients with advanced stage or deep invasion in GC tissues, which also implied lymph node metastasis and vascular invasion. Thus, CXCR4 could help predict patient prognosis and guide clinical diagnosis and treatment.

Keywords

CXCR4 Gastric cancer Prognosis Clinicopathology Meta-analysis 

Notes

Acknowledgments

This study was supported by China Scholarship Council, Shandong University Science Technology Innovation Fund (M2011e01, 2013349), and National Natural Science Foundation of China (81172404, 81372720). We were also very grateful to the help of Sandy Lab staff Huihui Kang et al. for their valuable advice.

Conflict of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2014

Authors and Affiliations

  • Mingzhi Han
    • 1
  • Shunzeng Lv
    • 1
    • 2
  • Ya Zhang
    • 3
  • Ruiyang Yi
    • 4
  • Bin Huang
    • 1
  • Hanhui Fu
    • 1
  • Ruixiang Bian
    • 5
  • Xingang Li
    • 1
  1. 1.Department of NeurosurgeryQilu Hospital of Shandong University and Brain Science Research Institute, Shandong UniversityJinanChina
  2. 2.Department of General Surgery, Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical CollegeBeijingChina
  3. 3.Department of HematologyShandong Provincial Hospital Affiliated to Shandong UniversityJinanChina
  4. 4.Biological Sciences DivisionUniversity of ChicagoChicagoUSA
  5. 5.Department of Joint SurgeryShandong Provincial Hospital Affiliated to Shandong UniversityJinanChina

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