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Embryonic stem cell-specific signature in cervical cancer

  • Review Article
  • Published:
Tumor Biology

Abstract

The wide range of invasive and noninvasive lesion phenotypes associated with high-risk human papillomavirus (HR-HPV) infection in cervical cancer (CC) indicates that not only the virus but also specific cervical epithelial cells in the transformation zone (TZ), such as stem cells (SCs), play an important part in the development of cervical neoplasia. In this review, we focused in an expression signature that is specific to embryonic SCs and to poorly differentiated cervical malignant tumors and we hypothesize that this expression signature may play an important role to promote cell growth, survival, colony formation, lack of adhesion, as well as cell invasion and migration in CC.

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Acknowledgements

We thank Dr. Hector Mayani Viveros (Investigador de Facultad de Medicina-UNAM y del Centro Medico Nacional Siglo XXI-IMSS), Dra. Vilma Maldonado Lagunas (Investigador de Facultad de Medicina-UNAM y del INMEGEN), Dr. Rodolfo Ocádiz-Delgado, Elizabeth Alvarez-Rios (Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del IPN, México) and Lic. Yunué Pliego Jiménez (Profesora de Lenguas Culturas del Centro de Enseñanza de Lenguas Extranjeras-UNAM [CELE-UNAM]) for helpful comments and critical reading of the manuscript.

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Authors and Affiliations

  1. Instituto de Fisiología Celular, Universidad Nacional Autónoma de México (UNAM), México, DF, México

    Jorge Organista-Nava & Yazmín Gómez-Gómez

  2. Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Av. IPN 2508, Colonia San Pedro Zacatenco, CP 07360, México, DF, México

    Jorge Organista-Nava, Yazmín Gómez-Gómez & Patricio Gariglio

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  1. Jorge Organista-Nava
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  2. Yazmín Gómez-Gómez
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  3. Patricio Gariglio
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Correspondence to Patricio Gariglio.

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J. Organista-Nava and Y. Gómez-Gómez contributed equally to the preparation of this manuscript.

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Organista-Nava, J., Gómez-Gómez, Y. & Gariglio, P. Embryonic stem cell-specific signature in cervical cancer. Tumor Biol. 35, 1727–1738 (2014). https://doi.org/10.1007/s13277-013-1321-y

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