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Tumor Biology

, Volume 35, Issue 3, pp 2253–2257 | Cite as

RETRACTED ARTICLE: CYP1A2 rs762551 polymorphism contributes to risk of lung cancer: A meta-analysis

  • Zheng Ma
  • Wei Guo
  • Taiqian Gong
  • Hui-Jun Niu
  • Ru-Wen Wang
  • Yao-Guang Jiang
Research Article

Abstract

Previous studies proposed that CYP1A2 rs762551 polymorphism might be associated with risk of lung cancer by influencing the function of CYP1A2. However, previous studies on the association between CYP1A2 rs762551 polymorphism and risk of lung cancer reported inconsistent findings. We performed a meta-analysis of the published case–control studies to assess the association between CYP1A2 rs762551 polymorphism and risk of lung cancer. PubMed and Embase were searched to identify relevant studies on the association between CYP1A2 rs762551 polymorphism and risk of lung cancer, and seven studies with a total of 3,320 subjects were finally included into the meta-analysis. The pooled odds ratio (OR) and 95 % confidence interval (95%CI) was calculated to evaluate the association. Meta-analysis of total studies showed that CYP1A2 rs762551 polymorphism contributed to risk of lung cancer under all four genetic models (C versus A: OR = 1.26, 95%CI 1.13 to 1.40, P < 0.001; CC versus AA: OR = 1.61, 95%CI 1.28 to 2.04, P < 0.001; CC versus AA/AC: OR = 1.52, 95%CI 1.11 to 2.09, P = 0.009; CC/AC versus AA: OR = 1.28, 95%CI 1.10 to 1.48, P = 0.001). Subgroup analysis based on ethnicity further suggested that CYP1A2 rs762551 polymorphism was associated with risk of lung cancer in Caucasians. These results from the meta-analysis suggest that CYP1A2 rs762551 polymorphism contributes to risk of lung cancer.

Keywords

CYP1A2 Lung cancer Meta-analysis Polymorphism 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Zheng Ma
    • 1
  • Wei Guo
    • 1
  • Taiqian Gong
    • 1
  • Hui-Jun Niu
    • 1
  • Ru-Wen Wang
    • 1
  • Yao-Guang Jiang
    • 1
  1. 1.Department of General Thoracic Surgery, Daping Hospital and Institute of Surgery Researchthe Third Millitary Medical UniversityYuzhong DistricPeople’s Republic of China

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