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Tumor Biology

, Volume 35, Issue 3, pp 1799–1803 | Cite as

Association between tumor necrosis factor-α rs1800629 polymorphism and risk of gastric cancer: a meta-analysis

  • Feng Zhu
  • Hang Zhao
  • Xiaohui Tian
  • Xiangjun Meng
Research Article

Abstract

Gastric cancer is mainly initiated by inflammation and chronic superficial gastritis, and tumor necrosis factor-α (TNF-α) is an inflammatory cytokine which plays an important role in the inflammation. TNF-α rs1800629 G/A polymorphism was proposed to be associated with gastric cancer risk, but previous studies on Caucasians reported conflicting results. We performed a meta-analysis to comprehensively assess the association between TNF-α rs1800629 polymorphism and gastric cancer risk in Caucasians. The pooled odds ratio (OR) with 95 % confidence interval (95 % CI) was calculated to assess the association. Eleven case–control studies with 7,427 subjects were finally included into the meta-analysis. Overall, TNF-α rs1800629 polymorphism was significantly associated with the increased risk of gastric cancer under four genetic comparison models (A versus G: OR = 1.32, 95 % CI 1.12–1.56, P = 0.001; AA versus GG: OR = 1.76, 95 % CI 1.37–2.26, P < 0.001; AA versus GG/GA: OR = 1.62, 95 % CI 1.27–2.07, P < 0.001; AA/GA versus GG: OR = 1.35, 95 % CI 1.14–1.60, P = 0.001). Meta-analysis of those studies with high quality showed that TNF-α rs1800629 polymorphism was still significantly associated with the increased risk of gastric cancer under four genetic comparison models. There was no risk of publication bias in the meta-analysis. The meta-analysis suggests that TNF-α rs1800629 polymorphism is associated with the increased risk of gastric cancer in Caucasians.

Keywords

Tumor necrosis factor-α Gastric cancer Polymorphism Meta-analysis 

Notes

Acknowledgment

This work was supported by the funding from NSFC (81072007).

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Feng Zhu
    • 1
  • Hang Zhao
    • 1
  • Xiaohui Tian
    • 1
  • Xiangjun Meng
    • 1
  1. 1.Department of Gastroenterology, Shanghai First People’s HospitalShanghai Jiao Tong UniversityShanghaiChina

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