Tumor Biology

, Volume 35, Issue 2, pp 1575–1580 | Cite as

Analysis of the association of interleukin-17 gene polymorphisms with gastric cancer risk and interaction with Helicobacter pylori infection in a Chinese population

  • Xukui Zhang
  • Luming Zheng
  • Yinggang Sun
  • Xiaoqiao ZhangEmail author
Research Article


We aimed to explore the association between interleukin-17 (IL-17) polymorphisms, Helicobacter pylori infection, and subsites in gastric cancer risk in a Chinese population. We genotyped three promoter polymorphisms (rs2275913G>A, rs3748067C>T, and rs763780T>C) of IL-17 in a case–control study of 260 gastric cancer patients and 512 healthy controls. An unconditional multiple logistical regression model was used to calculate the effects of IL-17 gene polymorphisms on gastric cancer risk. The rs2275913 AA (adjusted OR = 1.69, 95 % CI = 1.15–2.49) and rs3748067 TT (adjusted OR = 1.73, 95 % CI = 1.03–2.94) genotypes were associated with an increased risk of gastric cancer. We observed a significant interaction among rs2275913G>A, rs3748067C>T, and H. pylori infection on the risk of gastric cancer (p for interaction of 0.036 and 0.048, respectively). H. pylori infection subjects carrying the rs2275913 AA (adjusted OR = 2.48, 95 % CI = 1.49–4.12) and rs3748067 TT (adjusted OR = 2.54, 95 % CI = 1.34–5.12) genotypes had a greatly increased risk of gastric cancer compared to negative H. pylori participants. Similarly, subjects carrying the rs2275913 AA (adjusted OR = 2.09, 95 % CI = 1.25–3.45) and rs3748067 TT (adjusted OR = 2.29, 95 % CI = 1.20–4.20) genotypes had a moderately increased risk of noncardia gastric cancer. A significant interaction was observed between the rs2275913G>A and rs3748067C>T genotype and subsites of gastric cancer (p for interaction of 0.044 and 0.008, respectively). The rs2275913G>A and rs763780T>C polymorphisms increase gastric cancer risk, and interact with H. pylori infection and subsites. These findings could be helpful in identifying individuals at increased risk for developing gastric cancer.


Interleukin-17 Polymorphism H. pylori infection Gastric cancer Risk 



We thank the staff from the Department of General Surgery of PLA Jinan General Hospital and patients who provides blood samples for us.

Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Xukui Zhang
    • 1
  • Luming Zheng
    • 1
  • Yinggang Sun
    • 1
  • Xiaoqiao Zhang
    • 1
    Email author
  1. 1.Department of General SurgeryPLA Jinan General HospitalJinanChina

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