Tumor Biology

, Volume 35, Issue 2, pp 1331–1334 | Cite as

Serum carbohydrate antigen 19-9 and prognosis of patients with gastric cancer

  • Jiuchang Xiao
  • Xiaoyan He
  • Zengyan Wang
  • Jiying Hu
  • Fang Sun
  • Feng Qi
  • Shugang YangEmail author
  • Zhenyu XiaoEmail author
Research Article


Previous studies have assessed the prognostic role of serum carbohydrate antigen 19-9 (CA 19-9) concentration in patients with gastric cancer, but the findings from those studies were inconsistent. We searched the PubMed and Web of Science databases to find eligible studies assessing the prognostic role of CA 19-9 in patients with gastric cancer. Twelve studies with a total of 5,072 gastric cancer patients were finally included into the meta-analysis. The pooled hazard ratio (HR) with corresponding 95 % confidence interval (95 % CI) for overall survival were calculated to assess the prognostic role of CA 19-9 in patients with gastric cancer. Overall, elevated serum concentration of CA 19-9 (>37 U/mL) was associated with poorer overall survival in patients with gastric cancer (fixed-effects HR = 1.36, 95 % CI 1.24–1.48, P < 0.001). Subgroup analysis by study design further showed that elevated serum concentration of CA 19-9 was associated with poorer overall survival in patients with gastric cancer. There was no obvious risk of publication bias. Elevated concentration of serum CA 19-9 is associated with poorer overall survival in patients with gastric cancer.


Carbohydrate antigen 19-9 Gastric cancer Survival Meta-analysis 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Jiuchang Xiao
    • 1
  • Xiaoyan He
    • 2
  • Zengyan Wang
    • 3
  • Jiying Hu
    • 4
  • Fang Sun
    • 4
  • Feng Qi
    • 4
  • Shugang Yang
    • 5
    Email author
  • Zhenyu Xiao
    • 2
    Email author
  1. 1.Department of Clinical LaboratoryPeople’s Hospital of GanzhouGanzhouChina
  2. 2.Department of OncologyPeople’s Hospital of GanzhouGanzhouChina
  3. 3.Surgical CenterZhucheng People’s HospitalZhuchengChina
  4. 4.Department of Obstetrics and GynecologyMaternal and Child Health Hospital of WeifangWeifangChina
  5. 5.General and Hepatobiliary SurgeryZhucheng People’s HospitalZhuchengChina

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