Tumor Biology

, Volume 35, Issue 1, pp 573–579 | Cite as

Association of the interleukin-4Rα rs1801275 and rs1805015 polymorphisms with glioma risk

  • Jun Guo
  • Lei Shi
  • Min Li
  • Jin Xu
  • Shushan Yan
  • Chuang ZhangEmail author
  • Guan SunEmail author
Research Article


Potential single-nucleotide polymorphisms (SNPs) of interleukin-4 receptor alpha (IL-4Rα) rs1801275 and rs1805015 have been implicated in glioma risk; however, the findings of previous published case–control studies are conflicting and inconclusive. We performed the updated meta-analysis with the aim to provide a more precise estimate for the role of interleukin-4Rα SNPs in glioma risk. The pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were used to evaluate the strength of the gene association. Overall, the pooled analysis showed that the IL-4Rα rs1801275 polymorphism was associated with a decreased risk of glioma in the comparison of G vs. A (OR = 0.87, 95 % CI = 0.76–0.99, P OR = 0.041). Subgroup analysis by ethnicity revealed that the IL-4Rα rs1801275 variant G and GG + AG exerted a decreased risk effect on the development of glioma among Asians, but not Caucasians (G vs. A, OR = 0.81, 95 % CI = 0.69–0.95, P OR = 0.011; GG + AG vs. AA, OR = 0.80, 95 % CI = 0.66–0.96, P OR = 0.018). However, the IL-4Rα rs1805015 polymorphism did not modify the risk of glioma. Sensitivity analysis confirmed the reliability for all of the results. Our meta-analysis suggests that the polymorphism of IL-4Rα rs1801275 but not IL-4Rα rs1805015 plays a protective role in the glioma pathogenesis, particularly among Asians.


Interleukin-4Rα Glioma Single-nucleotide polymorphism Meta-analysis 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  1. 1.Department of NeurosurgeryFourth Affiliated Hospital of Nantong University, First Hospital of YanchengYanchengPeople’s Republic of China
  2. 2.Department of NeurosurgeryThe First People’s Hospital of Kunshan Affiliated with Jiangsu UniversitySuzhouPeople’s Republic of China
  3. 3.Department of NeurosurgeryJiangning Hospital Affiliated with Nanjing Medical UniversityNanjingPeople’s Republic of China
  4. 4.Department of Surgical OncologyThe Eighty-First Hospital of People’s Liberation ArmyNanjingPeople’s Republic of China
  5. 5.Department of Medical OncologyThe Eighty-First Hospital of People’s Liberation ArmyNanjingPeople’s Republic of China

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