Tumor Biology

, Volume 35, Issue 1, pp 447–453 | Cite as

XPC gene polymorphisms contribute to bladder cancer susceptibility: a meta-analysis

  • Qiang-Sheng Dai
  • Rui-Xi Hua
  • Rui-Fang Zeng
  • Jian-Ting Long
  • Zhen-Wei Peng
Research Article
First Online:
Received:
Accepted:

Abstract

Numerous studies have investigated the association between three polymorphisms (Lys939Gln, Ala499Val and PAT−/+) of Xeroderma pigmentosum group C (XPC) gene and bladder cancer susceptibility; however, the findings are inconclusive. In order to acquire a more precise estimation of the relationship, we performed a meta-analysis based on 10 studies including 3,934 cases and 4,269 controls for Lys939Gln, five studies including 2,113 cases and 2,249 controls for Ala499Val, and seven studies including 2,834 cases and 3,048 controls for PAT−/+ polymorphism. We searched publications from EMBASE, MEDLINE, and Chinese Biomedical. We calculated pooled odds ratio (OR) and 95 % confidence interval (CI) by using either fixed-effects or random-effects model according to the between-study heterogeneity. We found that all studied polymorphisms were individually associated with increased overall cancer risks, as shown by ORs (95 % CIs) below: the Lys939Gln (Gln/Gln vs. Lys/Lys: OR = 1.39, 95 % CI = 1.08–1.79; recessive model: OR = 1.42, 95 % CI = 1.11–1.83; and allele comparing: OR = 1.12, 95 % CI = 1.003–1.24), the Ala499Val (Val/Val vs. Ala/Ala: OR = 1.82, 95 % CI = 1.19–2.79; recessive model: OR = 1.70, 95 % CI = 1.18–2.46; and allele comparing: OR = 1.23, 95 % CI = 1.01–1.50), and the PAT−/+ (+/+ vs. −/−: OR = 1.36, 95 % CI = 1.03–1.79 and recessive model: OR = 1.34, 95 % CI = 1.06–1.70). Furthermore, stratification analyses demonstrated an increased risk for Asian populations as to the Lys939Gln and PAT−/+ whereas for Caucasian populations as to the Ala499Val polymorphism in the homozygous and recessive models. Despite some limitations, this meta-analysis suggests that XPC polymorphisms are associated with bladder cancer risk, but this association warrants further validation in well-designed studies with large sample sizes.

Keywords

Bladder cancer XPC Polymorphism Susceptibility Meta-analysis 

Abbreviations

NER

Nucleotide excision repair

SNP

Single nucleotide polymorphism

DRC

DNA repair capacity

XPC

Xeroderma pigmentosum complementation group C

CBM

Chinese Biomedical

OR

Odds ratio

CI

Confidence interval

HWE

Hardy–Weinberg equilibrium.

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Notes

Acknowledgements

We thank Jin-Hong Zhu for providing help in revision and modification of this paper. This work was supported by National Natural Science Foundation of China Grant 81101506.

Conflict of Interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Qiang-Sheng Dai
    • 1
  • Rui-Xi Hua
    • 1
  • Rui-Fang Zeng
    • 1
  • Jian-Ting Long
    • 1
  • Zhen-Wei Peng
    • 1
  1. 1.Department of Oncology, First Affiliated HospitalSun Yat-Sen UniversityGuangzhouPeople’s Republic of China

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