Tumor Biology

, Volume 35, Issue 1, pp 111–116 | Cite as

RETRACTED ARTICLE: Curcumin inhibits lung cancer progression and metastasis through induction of FOXO1

  • Zhen-Cai Li
  • Li-Ming Zhang
  • Hai-Bin Wang
  • Jun-Xun Ma
  • Jun-Zhong Sun
Research Article

Abstract

Recent population studies provide clues that the use of curcumin may be associated with reduced incidence and improved prognosis of certain cancers. In the present study, we demonstrated that curcumin acted as a growth inhibitor for lung cancer cells. Our results found that curcumin inhibited cell proliferation, which was associated with upregulation of the cyclin-dependent kinase inhibitors, p27 and p21, and downregulation of cyclin D1. In addition, we showed that curcumin induced the expression of forkhead box protein O1 (FOXO1) through activation of extracellular signal-regulated kinase 1/2 signaling. These findings provide evidence for a mechanism that may contribute to the antineoplastic effects of curcumin and justify further work to explore potential roles for activators of FOXO1 in the prevention and treatment of lung cancer.

Keywords

Curcumin Lung cancer FOXO1 ERK1/2 signaling 

Notes

Acknowledgment

This study was supported by the National Natural Science Foundation of China (No. 81071839), Capital Medical Development Foundation of China (2007-2040).

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Zhen-Cai Li
    • 1
  • Li-Ming Zhang
    • 2
  • Hai-Bin Wang
    • 3
  • Jun-Xun Ma
    • 3
  • Jun-Zhong Sun
    • 3
  1. 1.Department of Ultrasound, The First Affiliated HospitalGeneral Hospital of Chinese PLABeijingChina
  2. 2.No. 535 Hospital of Chinese People’s Liberation ArmyHuaihuaChina
  3. 3.Department of oncology, The First Affiliated HospitalGeneral Hospital of Chinese PLABeijingChina

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