Tumor Biology

, Volume 35, Issue 1, pp 55–60 | Cite as

T-cell infiltration and expressions of T lymphocyte co-inhibitory B7-H1 and B7-H4 molecules among colorectal cancer patients in northeast China’s Heilongjiang province

  • Ming Liang
  • Jingyuan Li
  • Dandan Wang
  • Shuchen Li
  • Yi Sun
  • Tiewei Sun
  • Jing Zhang
  • Xiaoning Chen
  • Qiang Li
  • Shibo Sun
Research Article

Abstract

Colorectal cancer has an extremely poor prognosis due to its high rate of recurrence and metastasis. The present study aimed to investigate the correlations between the B7-H1 and B7-H4 expressions as well as the clinicopathological characteristics and the prognosis of patients with colorectal cancer. We further inferred from these findings whether T lymphocyte co-inhibitory molecules (B7-H1 and B7-H4) led to a poor prognosis in Heilongjiang patients with colorectal cancer. Survival analysis revealed that the poor prognosis of these patients was unrelated to patient age, tumor size or histological grade, or lymph node metastasis, but was associated with TNM stage, high B7-H1 and B7-H4 expression levels. High B7-H1 and B7-H4 expressions were closely correlated with poor prognosis in patients with colorectal cancer. We speculate that the joint detection of these molecules may clinically apply for diagnosing and predicting poor prognosis of patients with colorectal cancer in northeast China’s Heilongjiang province. In addition, intervention of B7-H1 and B7-H4 may be beneficial for enhancement of immunity in these patients.

Keywords

Colorectal cancer B7-H1 B7-H4 Prognosis 

Notes

Acknowledgments

We thank for the support by Colleges and Universities in Heilongjiang Province Key Laboratory of Neurobiology topics (Liang Ming; 2013HLJKLNT-09); Heilongjiang Provincial Department of Education Science and Technology Research Project (12531296).

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Ming Liang
    • 1
    • 4
  • Jingyuan Li
    • 1
  • Dandan Wang
    • 2
  • Shuchen Li
    • 1
  • Yi Sun
    • 3
  • Tiewei Sun
    • 3
  • Jing Zhang
    • 3
  • Xiaoning Chen
    • 3
  • Qiang Li
    • 3
  • Shibo Sun
    • 3
  1. 1.Department of Infectious DiseasesThe Second Affiliated Hospital of Harbin Medical UniversityHarbinChina
  2. 2.Wu Lian De Memorial HospitalThe First Affiliated Hospital of Harbin Medical UniversityHarbinChina
  3. 3.Department of SurgeryThe Second Affiliated Hospital of Harbin Medical UniversityHarbinChina
  4. 4.Department of Neurobiology, Harbin Medical University Provincial Key Lab of NeurobiologyHarbin Medical UniversityHarbinChina

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