Tumor Biology

, Volume 35, Issue 1, pp 27–32 | Cite as

RETRACTED ARTICLE: Association of XRCC1 gene single nucleotide polymorphisms and susceptibility to pancreatic cancer in Chinese

  • Hongxu Chen
  • Chun Tang
  • Menggang Liu
  • Bo Zhou
  • Yi Kuang
  • Tao Yuan
  • Ping Chen
Research Article


The human X-ray repair cross-complementing group 1 gene (XRCC1) is an important candidate gene for affecting pancreatic cancer (PC) risk. The objective of this study was to detect whether the c.1471G > A and c.1686C > G polymorphisms of XRCC1 gene influence PC risk. The association of XRCC1 genetic variants with PC risk was analyzed in 328 PC patients and 350 controls by the polymerase chain reaction-restriction fragment length polymorphism and created restriction site-polymerase chain reaction method. Our data suggested that the genotypes and alleles from these two genetic variants were statistically associated with PC risk. For c.1471G > A, the AA genotype was associated with the decreased risk of developing PC compared to GG wild genotype (odds ratio (OR) = 0.43, 95 % confidence intervals (CI) 0.26–0.70, chi-squared (χ 2) = 11.91, P = 0.001). For c.1686C > G, the risk of PC was significantly lower for GG genotype in comparing to CC wild genotype (OR = 0.48, 95 % CI 0.29–0.81, χ 2 = 7.98, P = 0.005). The A allele of c.1471G > A and G allele of c.1686C > G genetic variants could contribute to decrease the risk of PC (for c.1471G > A: A vs G, OR = 0.65, 95 % CI 0.52–0.82, χ 2 = 13.71, P < 0.001, for c.1686C > G: G vs C, OR = 0.70, 95 % CI 0.55–0.88, χ 2 = 9.42, P = 0.002). Our findings indicate that the c.1471G > A and c.1686C > G polymorphisms of XRCC1 gene are associated with PC risk in Chinese population.


Pancreatic cancer XRCC1 gene Cancer susceptibility Single nucleotide polymorphisms Molecular markers 


Conflict of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Hongxu Chen
    • 1
  • Chun Tang
    • 1
  • Menggang Liu
    • 1
  • Bo Zhou
    • 1
  • Yi Kuang
    • 1
  • Tao Yuan
    • 1
  • Ping Chen
    • 1
  1. 1.Department of Hepatobiliary Surgery, Daping HospitalThe Third Military Medical UniversityChongqingPeople’s Republic of China

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