Advertisement

Tumor Biology

, Volume 35, Issue 1, pp 27–32 | Cite as

RETRACTED ARTICLE: Association of XRCC1 gene single nucleotide polymorphisms and susceptibility to pancreatic cancer in Chinese

  • Hongxu Chen
  • Chun Tang
  • Menggang Liu
  • Bo Zhou
  • Yi Kuang
  • Tao Yuan
  • Ping Chen
Research Article

Abstract

The human X-ray repair cross-complementing group 1 gene (XRCC1) is an important candidate gene for affecting pancreatic cancer (PC) risk. The objective of this study was to detect whether the c.1471G > A and c.1686C > G polymorphisms of XRCC1 gene influence PC risk. The association of XRCC1 genetic variants with PC risk was analyzed in 328 PC patients and 350 controls by the polymerase chain reaction-restriction fragment length polymorphism and created restriction site-polymerase chain reaction method. Our data suggested that the genotypes and alleles from these two genetic variants were statistically associated with PC risk. For c.1471G > A, the AA genotype was associated with the decreased risk of developing PC compared to GG wild genotype (odds ratio (OR) = 0.43, 95 % confidence intervals (CI) 0.26–0.70, chi-squared (χ 2) = 11.91, P = 0.001). For c.1686C > G, the risk of PC was significantly lower for GG genotype in comparing to CC wild genotype (OR = 0.48, 95 % CI 0.29–0.81, χ 2 = 7.98, P = 0.005). The A allele of c.1471G > A and G allele of c.1686C > G genetic variants could contribute to decrease the risk of PC (for c.1471G > A: A vs G, OR = 0.65, 95 % CI 0.52–0.82, χ 2 = 13.71, P < 0.001, for c.1686C > G: G vs C, OR = 0.70, 95 % CI 0.55–0.88, χ 2 = 9.42, P = 0.002). Our findings indicate that the c.1471G > A and c.1686C > G polymorphisms of XRCC1 gene are associated with PC risk in Chinese population.

Keywords

Pancreatic cancer XRCC1 gene Cancer susceptibility Single nucleotide polymorphisms Molecular markers 

Notes

Conflict of interest

None

References

  1. 1.
    Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin. 2007;57:43–66.CrossRefPubMedGoogle Scholar
  2. 2.
    Tanaka M, Okazaki T, Suzuki H, Abbruzzese JL, Li D. Association of multi-drug resistance gene polymorphisms with pancreatic cancer outcome. Cancer. 2011;117:744–51.CrossRefPubMedGoogle Scholar
  3. 3.
    Nakao M, Hosono S, Ito H, Watanabe M, Mizuno N, Sato S, et al. Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese. J Epidemiol. 2012;22:477–83.CrossRefPubMedGoogle Scholar
  4. 4.
    Li D, Frazier M, Evans DB, Hess KR, Crane CH, Jiao L, et al. Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. J Clin Oncol. 2006;24:1720–8.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Lowenfels AB, Maisonneuve P. Epidemiology and risk factors for pancreatic cancer. Best Pract Res Clin Gastroenterol. 2006;20:197–209.CrossRefPubMedGoogle Scholar
  6. 6.
    Larsson SC, Orsini N, Wolk A. Body mass index and pancreatic cancer risk: a meta-analysis of prospective studies. Int J Cancer. 2007;120:1993–8.CrossRefPubMedGoogle Scholar
  7. 7.
    Luo J, Iwasaki M, Inoue M, Sasazuki S, Otani T, Ye W, et al. Body mass index, physical activity and the risk of pancreatic cancer in relation to smoking status and history of diabetes: a large-scale population-based cohort study in Japan–the JPHC study. Cancer Causes Control. 2007;18:603–12.CrossRefPubMedGoogle Scholar
  8. 8.
    Duell EJ, Holly EA, Bracci PM, Wiencke JK, Kelsey KT. A population-based study of the Arg399Gln polymorphism in X-ray repair cross-complementing group 1 (XRCC1) and risk of pancreatic adenocarcinoma. Cancer Res. 2002;62:4630–6.PubMedGoogle Scholar
  9. 9.
    Li D, Li Y, Jiao L, Chang DZ, Beinart G, Wolff RA, et al. Effects of base excision repair gene polymorphisms on pancreatic cancer survival. Int J Cancer. 2007;120:1748–54.CrossRefPubMedPubMedCentralGoogle Scholar
  10. 10.
    McWilliams RR, Bamlet WR, Cunningham JM, Goode EL, de Andrade M, Boardman LA, et al. Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk. Cancer Res. 2008;68:4928–35.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Li J, Bondy ML, Hassan MM, Wolff RA, Evans DB, Abbruzzese JL, et al. Selected polymorphisms of DNA repair genes and risk of pancreatic cancer. Cancer Detect Prev. 2006;30:284–91.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Haliassos A, Chomel JC, Tesson L, Baudis M, Kruh J, Kaplan JC, et al. Modification of enzymatically amplified DNA for the detection of point mutations. Nucleic Acids Res. 1989;17:3606.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Yuan ZR, Li J, Li JY, Gao X, Xu SZ. SNPs identification and its correlation analysis with milk somatic cell score in bovine MBL1 gene. Mol Biol Rep. 2013;40:7–12.CrossRefPubMedGoogle Scholar
  14. 14.
    Yuan ZR, Li JY, Li J, Zhang LP, Gao X, Gao HJ, et al. Investigation on BRCA1 SNPs and its effects on mastitis in Chinese commercial cattle. Gene. 2012;505:190–4.CrossRefPubMedGoogle Scholar
  15. 15.
    Yuan ZR, Li JY, Li J, Gao X, Xu SZ. Effects of DGAT1 gene on meat and carcass fatness quality in Chinese commercial cattle. Mol Biol Rep. 2013;40:1947–54.CrossRefPubMedGoogle Scholar
  16. 16.
    Zhao CJ, Li N, Deng XM. The establishment of method for identifying SNP genotype by CRS-PCR. Yi Chuan. 2003;25:327–9.PubMedGoogle Scholar
  17. 17.
    Lowenfels AB, Maisonneuve P. Environmental factors and risk of pancreatic cancer. Pancreatology. 2003;3:1–7.CrossRefPubMedGoogle Scholar
  18. 18.
    Landi S. Genetic predisposition and environmental risk factors to pancreatic cancer: a review of the literature. Mutat Res. 2009;681:299–307.CrossRefPubMedGoogle Scholar
  19. 19.
    Lin Y, Tamakoshi A, Kawamura T, Inaba Y, Kikuchi S, Motohashi Y, et al. An epidemiological overview of environmental and genetic risk factors of pancreatic cancer. Asian Pac J Cancer Prev. 2001;2:271–80.PubMedGoogle Scholar
  20. 20.
    Chu D, Kohlmann W, Adler DG. Identification and screening of individuals at increased risk for pancreatic cancer with emphasis on known environmental and genetic factors and hereditary syndromes. JOP. 2010;11:203–12.PubMedGoogle Scholar
  21. 21.
    Nitsche C, Simon P, Weiss FU, Fluhr G, Weber E, Gartner S, et al. Environmental risk factors for chronic pancreatitis and pancreatic cancer. Dig Dis. 2011;29:235–42.CrossRefPubMedGoogle Scholar
  22. 22.
    Hung RJ, Hall J, Brennan P, Boffetta P. Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review. Am J Epidemiol. 2005;162:925–42.CrossRefPubMedGoogle Scholar
  23. 23.
    Mandal RK, Mittal T, Kapoor R, Mittal RD. NER and BER repair gene polymorphisms in a healthy north Indian cohort and comparison with different ethnic groups worldwide. Asian Pac J Cancer Prev. 2010;11:1601–4.PubMedGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Hongxu Chen
    • 1
  • Chun Tang
    • 1
  • Menggang Liu
    • 1
  • Bo Zhou
    • 1
  • Yi Kuang
    • 1
  • Tao Yuan
    • 1
  • Ping Chen
    • 1
  1. 1.Department of Hepatobiliary Surgery, Daping HospitalThe Third Military Medical UniversityChongqingPeople’s Republic of China

Personalised recommendations