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Tumor Biology

, Volume 34, Issue 6, pp 4073–4079 | Cite as

Single nucleotide polymorphism 6q25.1 rs2046210 and increased risk of breast cancer

  • Jing Pei
  • Fang Li
  • Benzhong Wang
Research Article

Abstract

The onset and development of breast cancer (BC) are influenced by many factors, including the single nucleotide polymorphism (SNP) rs2046210 at 6q25.1. However, studies of the potential association between rs2046210 at 6q25.1 and risk of BC have given inconsistent results. We performed a meta-analysis to address this controversy. PubMed, EMBASE, and Web of Science were systematically searched to identify relevant studies. Odds ratios (ORs) with 95 % confidence intervals (CIs) were calculated to assess the strength of the association between this SNP and risk of BC. A total of 14 studies are included in the meta-analysis, involving 123,085 cases and 120,761 controls. The A-allele, AA/GA, and AA genotypes were significantly associated with increased risk of BC (A-allele vs. G-allele: OR = 1.20, 95%CI = 1.15–1.25, P for heterogeneity < 0.0001; AA/GA vs. GG: OR = 1.22, 95%CI = 1.16–1.28, P for heterogeneity < 0.0001; AA vs. GA/GG: OR = 1.18, 95%CI = 1.13–1.24, P for heterogeneity = 0.064). In further stratified analysis by ethnicity, the elevated risks were found in Europeans and Asians, while there was no significant association detected in African population. In the subgroup analysis based on sample size and source of control, significant results were observed in all the subgroups. There was evidence of heterogeneity (P < 0.10), which largely disappeared after stratification by ethnicity. In summary, this meta-analysis suggests the participation of rs2046210 at 6q25.1 in the susceptibility for BC, especially in Europeans and Asians.

Keywords

6q25.1 rs2046210 SNP Single nucleotide polymorphism Variant and breast cancer (BC) 

Notes

Conflicts of interest

None.

Supplementary material

13277_2013_997_MOESM1_ESM.docx (353 kb)
ESM 1 (DOCX 353 kb)

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  1. 1.The Department of Breast SurgeryThe First Affiliated Hospital of Anhui Medical UniversityHefeiChina
  2. 2.Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghaiChina

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