Tumor Biology

, Volume 34, Issue 6, pp 4059–4063 | Cite as

RETRACTED ARTICLE: Association between glutathione S-transferase M 1 null genotype and risk of ovarian cancer: a meta-analysis

Research Article
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Abstract

Though previous studies investigated the association between glutathione S-transferase M 1 (GSTM1) null genotype and ovarian cancer risk, the effect of GSTM1 null genotype on ovarian cancer risk was still unclear. To comprehensively quantify the association between GSTM1 null genotype and ovarian cancer risk, we performed a meta-analysis. Eleven studies from ten publications were identified from PubMed database. The pooled odds ratio (OR) with its 95 % confidence interval (CI) was used to assess the association. Meta-analysis of the total 11 studies showed that GSTM1 null genotype was not associated with ovarian cancer risk (OR = 1.03, 95 % CI 0.92–1.14, P = 0.625). The cumulative meta-analyses showed a trend of no association between GSTM1 null genotype and ovarian cancer risk as information accumulated by year. There was no evidence of publication bias in the meta-analysis. Meta-analysis of the 11 available studies shows that GSTM1 null genotype is not associated with ovarian cancer risk.

Keywords

Ovarian cancer GSTM1 Meta-analysis Polymorphism 

Notes

Conflicts of interests

None.

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  1. 1.Department of GynecologyShanghai First Maternity and Infant Hospital, Tongji University School of MedicineShanghaiChina

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