Tumor Biology

, Volume 34, Issue 6, pp 3859–3863 | Cite as

Tumor necrosis factor-α 238 G/A polymorphism and gastric cancer risk: a meta-analysis

  • Jian-yong Yu
  • Li Li
  • Heng Ma
  • Kai Liu
  • Xurui Cheng
  • Yan-liang Li
  • Xi-lin Song
Research Article


Though many studies were performed to assess the association between tumor necrosis factor-α (TNF-α) 238 G/A polymorphism and gastric cancer risk, there were no conclusive findings. A meta-analysis of previous published studies was performed to get a comprehensive assessment of the association between TNF-α 238 G/A polymorphisms and gastric cancer. The pooled odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were calculated to assess the association. Fifteen studies with a total of 7,795 participants were finally included into this meta-analysis. Overall, there was an obvious association between TNF-α 238 G/A polymorphism and increased risk of gastric cancer (A vs. G: OR = 1.32, 95 % CI 1.02–1.72, P = 0.036; GA vs. GG: OR = 1.32, 95 % CI 1.01–1.72, P = 0.042; and AA/GA vs. GG: OR = 1.34, 95 % CI 1.02–1.76, P = 0.036). Subgroup analysis by ethnicity showed the statistically significant association between TNF-α 238 G/A polymorphism and gastric cancer was limited to Asian populations (A vs. G: OR = 1.59, 95 % CI 1.29–1.97, P < 0.001; GA vs. GG: OR = 1.63, 95 % CI 1.29–2.04, P < 0.001; and AA/GA vs. GG: OR = 1.64, 95 %CI 1.31–2.05, P < 0.001), and there was no obvious association in Caucasians. In conclusion, TNF-α 238 G/A polymorphism is significantly associated with increased risk of gastric cancer, especially in Asians.


TNF-α 238 G/A a Gastric cancer Polymorphism Meta-analysis 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Jian-yong Yu
    • 1
  • Li Li
    • 2
  • Heng Ma
    • 1
  • Kai Liu
    • 1
  • Xurui Cheng
    • 1
  • Yan-liang Li
    • 1
  • Xi-lin Song
    • 1
  1. 1.Department of Gastrointestinal SurgeryShandong Cancer HospitalJinanChina
  2. 2.Department of Trauma SurgeryWendeng Osteopathic HospitalWendengChina

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