Tumor Biology

, Volume 34, Issue 6, pp 3363–3369 | Cite as

Human papillomavirus is independent prognostic factor on outcome of oropharyngeal squamous cell carcinoma

  • Deniz Tural
  • Olgun Eliçin
  • Şebnem Batur
  • Deniz Arslan
  • Büge Öz
  • Süheyla Serdengeçti
  • Ömer Uzel
Research Article

Abstract

The primary aim of this study is to assess differences in patients’ clinicopathological characteristics based on human papillomavirus (HPV) status and the effect of HPV status on outcome in oropharyngeal squamous cell carcinoma (OSCC). The medical registry of 81 patients who were treated for OSCC was retrospectively analyzed. Factors that are found to be predictive of poor overall survival and event risk by univariate Cox’s regression analysis included age greater than 60 years (hazard ratio (HR), 1.2, p = 0.02, and HR, 1.12, p = 0.05), poor Eastern Cooperative Oncology Group performance (HR,1.6, p = 0.01, and HR,1.32, p = 0.001), advanced T stage (HR,1.38, p = 0.01, and HR,1.4, p = 0.02), advanced N stage(HR, 1.6, p = 0.03, and HR,1.5, p = 0.03), smoking history (HR,1.4, p = 0.04, and HR, 1.6, p = 0.03), and HPV-negative patients (HR, 2.4, p = 0.012, and HR, 1.8, p = 0.01). HPV-positive tumors were estimated to have a 36 % reduction in risk of death and 32 % reduction in event risk. HPV status had independent prognostic effects on survival and event-free survival.

Keywords

Oropharyngeal squamous cell carcinoma Treatment modality HPV status Patient characteristics Outcome 

Notes

Conflicts of interest

None

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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Deniz Tural
    • 1
  • Olgun Eliçin
    • 2
  • Şebnem Batur
    • 3
  • Deniz Arslan
    • 4
  • Büge Öz
    • 3
  • Süheyla Serdengeçti
    • 1
  • Ömer Uzel
    • 2
  1. 1.Division of Medical Oncology, Department of Internal Medicine, Cerrahpasa Medical FacultyIstanbul UniversityIstanbulTurkey
  2. 2.Department of Radiation Oncology, Cerrahpasa Medical FacultyIstanbul UniversityIstanbulTurkey
  3. 3.Department of Pathology, Cerrahpasa Medical FacultyIstanbul UniversityIstanbulTurkey
  4. 4.Division of Medical Oncology, Department of Internal Medicine, Medical FacultyAkdeniz UniversityAntalyaTurkey

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