Tumor Biology

, Volume 34, Issue 5, pp 2507–2509 | Cite as

Circulating tumor cells in high-risk nonmetastatic colorectal cancer

  • Paola Gazzaniga
  • Walter Gianni
  • Cristina Raimondi
  • Angela Gradilone
  • Giuseppe Lo Russo
  • Flavia Longo
  • Orietta Gandini
  • Silverio Tomao
  • Luigi Frati
Research Commentary

Abstract

The identification of patients at higher risk of recurrence after primary colorectal cancer resection is currently one of the challenges facing medical oncologists. Circulating tumor cell (CTC) may represent a surrogate marker of an early spread of disease in patients without overt metastases. Thirty-seven high-risk stages II–III colorectal cancer patients were evaluated for the presence of CTC. Enumeration of CTCs in 7.5 ml of blood was carried out with the FDA-cleared CellSearch system. CTC count was performed after primary tumor resection and before the start of adjuvant therapy. CTC was detected in 22 % of patients with a significant correlation with regional lymph nodes involvement and stage of disease. No significant correlation was found among the presence of CTC and other clinicopathological parameters. These data suggest that CTCs detection might help in the selection of high-risk stage II colorectal cancer patient candidates for adjuvant chemotherapy.

Keywords

Circulating tumor cells Early colorectal cancer Prognosis 

Notes

Acknowledgments

This work was supported by Ar.Ger.On onlus.

Conflicts of interest

None.

References

  1. 1.
    Cohen SJ, Punt CJ, Iannotti N, Saidman BH, Sabbath KD, Gabrail NY, et al. Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer. Ann Oncol. 2009;20:1223–9.CrossRefPubMedGoogle Scholar
  2. 2.
    Sastre J, Maestro ML, Puente J, Veganzones S, Alfonso R, Rafael S, et al. Circulating tumor cells in colorectal cancer: correlation with clinical and pathological variables. Ann Oncol. 2008;19:935–8.CrossRefPubMedGoogle Scholar
  3. 3.
    Maestro LM, Sastre J, Rafael SB, Veganzones SB, Vidaurreta M, Martín M, et al. Circulating tumor cells in solid tumor in metastatic and localized stages. Anticancer Res. 2009;29:4839–43.PubMedGoogle Scholar
  4. 4.
    Thorsteinsson M, Söletormos G, Jess P. Low number of detectable circulating tumor cells in non-metastatic colon cancer. Anticancer Res. 2011;31:613–7.PubMedGoogle Scholar
  5. 5.
    Lucci A, Hall CS, Lodhi AK, Bhattacharyya A, Anderson AE, Xiao L, et al. Circulating tumour cells in non-metastatic breast cancer: a prospective study. Lancet Oncol. 2012;13:688–95.CrossRefPubMedGoogle Scholar
  6. 6.
    Thorsteinsson M, Jess P. The clinical significance of circulating tumor cells in non-metastatic colorectal cancer—a review. Eur J Surg Oncol. 2011;37:459–65.CrossRefPubMedGoogle Scholar
  7. 7.
    Rack B, Schindlbec C, Andergassen U, Lorenz R, Zwingers T, Schneeweiss A, Lichtenegger W, Beckmann MW, Sommer H, Pantel K, Fries K, Janni W. Prognostic relevance of circulating tumor cells in the peripheral blood of primary breast cancer patients. 33rd Annual San Antonio Breast Cancer Symposium; San Antonio, TX, USA; Dec 8–12, 2010. Abstr 503.Google Scholar
  8. 8.
    Gazzaniga P, Gradilone A, de Berardinis E, Busetto GM, Raimondi C, Gandini O, et al. Prognostic value of circulating tumor cells in nonmuscle invasive bladder cancer: a Cell Search analysis. Ann Oncol. 2012;23:2352–6.CrossRefPubMedGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Paola Gazzaniga
    • 1
  • Walter Gianni
    • 2
  • Cristina Raimondi
    • 1
  • Angela Gradilone
    • 1
  • Giuseppe Lo Russo
    • 3
  • Flavia Longo
    • 1
  • Orietta Gandini
    • 1
  • Silverio Tomao
    • 3
  • Luigi Frati
    • 4
  1. 1.Department of Molecular MedicineSapienza University of RomeRomeItaly
  2. 2.Scientific Direction, HCP Study CenterIRCCS San Raffaele PisanaRomeItaly
  3. 3.Department of Medico-Surgical Sciences and BiotechnologiesSapienza University of RomeRomeItaly
  4. 4.Department of Experimental MedicineSapienza University of RomeRomeItaly

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