Tumor Biology

, Volume 34, Issue 3, pp 1825–1831

GSTP1 Ala114Val polymorphism and colorectal cancer risk: a meta-analysis

  • Fuqiang Li
  • Bing Xu
  • Zili Yang
  • Yijun Wu
  • Shuai Dong
  • Jiajie Qian
Research Article

Abstract

Studies investigating the association between cytochrome glutathione S-transferase P1 (GSTP1) Ala114Val polymorphism and colorectal cancer (CRC) risk report conflicting results. The aim of this study was to quantitatively summarize the evidence for such a relationship. Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine databases. Summary odds ratios (ORs) and 95 % confidence intervals (95 % CIs) for GSTP1 polymorphism and CRC were calculated in a fixed effects model (the Mantel–Haenszel method) and a random effects model (the DerSimonian and Laird method) when appropriate. The pooled ORs were performed for co-dominant model (ValVal vs. AlaAla, AlaVal vs. AlaAla), dominant model (ValVal + AlaVal vs. AlaAla), and recessive model (ValVal vs. AlaVal + AlaAla). This meta-analysis included seven case–control studies, which included 3,173 CRC cases and 3,323 controls. Overall, the variant genotypes (ValVal and AlaVal) of the Ala114Val were not associated with CRC risk when compared with the wild-type AlaAla homozygote. Similarly, no associations were found in the dominant and recessive models. When stratifying for ethnicity, Hardy–Weinberg equilibrium in controls, study sample size, and source of controls, a significantly increased risk was observed among Asians (AlaVal vs. AlaAla, OR = 1.67, 95 % CI = 1.08–2.59; dominant model, OR = 1.74, 95 % CI = 1.14–2.67). No heterogeneity or publication bias was found in the present study. This meta-analysis suggests that the GSTP1 Ala114Val polymorphism may not be associated with CRC risk, while the observed increase in risk of CRC may be due to small-study bias.

Keywords

Colorectal cancer Polymorphism GSTP1 Meta-analysis 

Abbreviations

CRC

Colorectal cancer

OR

Odds ratio

CI

Confidence interval

GSTP1

Glutathione S-transferase P1

SNP

Single-nucleotide polymorphism

HWE

Hardy–Weinberg equilibrium

References

  1. 1.
    Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.PubMedCrossRefGoogle Scholar
  2. 2.
    Ferlay J, Parkin DM, Steliarova-Foucher E. Estimates of cancer incidence and mortality in Europe in 2008. Eur J Cancer. 2010;46:765–81.PubMedCrossRefGoogle Scholar
  3. 3.
    Sung JJ, Lau JY, Goh KL. Leung WK; Asia Pacific Working Group on Colorectal Cancer. Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol. 2005;6:871–6.PubMedCrossRefGoogle Scholar
  4. 4.
    Zhao P, Dai M, Chen W, et al. Cancer trends in China. Jpn J Clin Oncol. 2010;40:281–5.PubMedCrossRefGoogle Scholar
  5. 5.
    Lichtenstein P, Holm NV, Verkasalo PK, et al. Environmental and heritable factors in the causation of cancer—analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med. 2000;343:78–85.PubMedCrossRefGoogle Scholar
  6. 6.
    Cleary SP, Cotterchio M, Shi E, Gallinger S, Harper P. Cigarette smoking, genetic variants in carcinogen-metabolizing enzymes, and colorectal cancer risk. Am J Epidemiol. 2010;172:1000–14.PubMedCrossRefGoogle Scholar
  7. 7.
    Mannervik B, Danielson UH. Glutathione transferases—structure and catalytic activity. CRC Crit Rev Biochem. 1988;23:283–337.PubMedCrossRefGoogle Scholar
  8. 8.
    Mannervik B. The isoenzymes of glutathione transferase. Adv Enzymol Relat Areas Mol Biol. 1985;57:357–417.PubMedGoogle Scholar
  9. 9.
    Eaton DL, Bammler TK. Concise review of the glutathione S-transferases and their significance to toxicology. Toxicol Sci. 1999;49:156–64.PubMedCrossRefGoogle Scholar
  10. 10.
    Evans WE, Relling MV. Pharmacogenomics: translating functional genomics into rational therapeutics. Science. 1999;286:487–91.PubMedCrossRefGoogle Scholar
  11. 11.
    Hengstler JG, Arand M, Herrero ME, Oesch F. Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility. Recent Results Cancer Res. 1998;154:47–85.PubMedCrossRefGoogle Scholar
  12. 12.
    Zimniak P, Nanduri B, Pikula S, et al. Naturally occurring human glutathione S-transferase GST-PI-1isoforms with isoleucine and valine in position 105 differ in enzymatic properties. Eur J Biochem. 1994;15:893–9.CrossRefGoogle Scholar
  13. 13.
    Ali-Osman F, Akande O, Antoun G, Mao JX, Buolamwini J. Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins. J Biol Chem. 1997;272:10004–12.PubMedCrossRefGoogle Scholar
  14. 14.
    Watson MA, Stewart RK, Smith GB, Massey TE, Bell DA. Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution. Carcinogenesis. 1998;19:275–80.PubMedCrossRefGoogle Scholar
  15. 15.
    Cochran WG. The combination of estimates from different experiments. Biometrics. 1954;10:101–29.CrossRefGoogle Scholar
  16. 16.
    Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60.PubMedCrossRefGoogle Scholar
  17. 17.
    Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959;22:719–48.PubMedGoogle Scholar
  18. 18.
    DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7:177–88.PubMedCrossRefGoogle Scholar
  19. 19.
    Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088–101.PubMedCrossRefGoogle Scholar
  20. 20.
    Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629–34.PubMedCrossRefGoogle Scholar
  21. 21.
    Welfare M, Monesola Adeokun A, Bassendine MF, Daly AK. Polymorphisms in GSTP1, GSTM1, and GSTT1 and susceptibility to colorectal cancer. Cancer Epidemiol Biomarkers Prev. 1999;8:289–92.PubMedGoogle Scholar
  22. 22.
    Sachse C, Smith G, Wilkie MJ, et al. A pharmacogenetic study to investigate the role of dietary carcinogens in the etiology of colorectal cancer. Carcinogenesis. 2002;23:1839–49.PubMedCrossRefGoogle Scholar
  23. 23.
    Landi S, Gemignani F, Moreno V, et al. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. Pharmacogenet Genomics. 2005;15:535–46.PubMedCrossRefGoogle Scholar
  24. 24.
    Küry S, Buecher B, Robiou-du-Pont S, et al. Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study. BMC Cancer. 2008;8:326.PubMedCrossRefGoogle Scholar
  25. 25.
    Wang J, Jiang J, Zhao Y, et al. Genetic polymorphisms of glutathione S-transferase genes and susceptibility to colorectal cancer: a case–control study in an Indian population. Cancer Epidemiol. 2011;35:66–72.PubMedCrossRefGoogle Scholar
  26. 26.
    Sainz J, Rudolph A, Hein R, et al. Association of genetic polymorphisms in ESR2, HSD17B1, ABCB1, and SHBG genes with colorectal cancer risk. Endocr Relat Cancer. 2011;18:265–76.PubMedCrossRefGoogle Scholar
  27. 27.
    Ebrahimkhani S, Asgharian AM, Nourinaier B, et al. Association of GSTM1, GSTT1, GSTP1 and CYP2E1 single nucleotide polymorphisms with colorectal cancer in Iran. Pathol Oncol Res. 2012;18:651–6.PubMedCrossRefGoogle Scholar
  28. 28.
    Terrier P, Townsend AJ, Coindre JM, Triche TJ, Cowan KH. An immunohistochemical study of pi class glutathione S-transferase expression in normal human tissue. Am J Pathol. 1990;137:845–53.PubMedGoogle Scholar
  29. 29.
    Moscow JA, Fairchild CR, Madden MJ, et al. Expression of anionic glutathione-S-transferase and P-glycoprotein genes in human tissues and tumors. Cancer Res. 1989;49:1422–8.PubMedGoogle Scholar
  30. 30.
    Saarikoski ST, Voho A, Reinikainen M, et al. Combined effect of polymorphic GST genes on individual susceptibility to lung cancer. Int J Cancer. 1998;77:516–21.PubMedCrossRefGoogle Scholar
  31. 31.
    Serrano NC, Díaz L, Páez MC, et al. Angiotensin-converting enzyme I/D polymorphism and preeclampsia risk: evidence of small-study bias. PLoS Med. 2006;3:e520.PubMedCrossRefGoogle Scholar
  32. 32.
    Li Y, Liu F, Tan SQ, Wang Y, Li SW. Estrogen receptor-alpha gene PvuII (T/C) and XbaI (A/G) polymorphisms and endometriosis risk: a meta-analysis. Gene. 2012;508:41–8.PubMedCrossRefGoogle Scholar
  33. 33.
    Economopoulos KP, Sergentanis TN. GSTM1, GSTT1, GSTP1, GSTA1 and colorectal cancer risk: a comprehensive meta-analysis. Eur J Cancer. 2010;46:1617–31.PubMedCrossRefGoogle Scholar
  34. 34.
    Gao Y, Pan X, Su T, Mo Z, Cao Y, Gao F. Glutathione S-transferase P1 Ile105Val polymorphism and colorectal cancer risk: a meta-analysis and HuGE review. Eur J Cancer. 2009;45:3303–14.PubMedCrossRefGoogle Scholar
  35. 35.
    Benhamou S, Lee WJ, Alexandrie AK, et al. Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk. Carcinogenesis. 2002;23:1343–50.PubMedCrossRefGoogle Scholar

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Fuqiang Li
    • 1
  • Bing Xu
    • 2
  • Zili Yang
    • 1
  • Yijun Wu
    • 1
  • Shuai Dong
    • 1
  • Jiajie Qian
    • 1
  1. 1.Department of Gastrointestinal Surgery, The First Affiliated HospitalZhejiang UniversityHangzhouChina
  2. 2.Department of General Surgery, Renmin HospitalHubei University of MedicineShiyanChina

Personalised recommendations