Tumor Biology

, Volume 34, Issue 3, pp 1431–1440 | Cite as

RETRACTED ARTICLE: Association of GSTT1 gene polymorphisms with the risk of prostate cancer: an updating meta-analysis

  • Jihong Wang
  • Yuemin Xu
  • Qiang Fu
  • Jianjun Yu
  • Zhong Chen
  • Zhangshun Liu
  • Chao Li
  • Hui Guo
  • Mingkai Xie
Research Article


It has been demonstrated that the glutathione S-transferase (GST) superfamily helps remove carcinogens from the body and thus might be associated with prostate cancer risk. In recent years, GSTT1 polymorphism has been extensively studied as a potential prostate cancer risk factor; however, the results are inconsistent. To investigate the association between GSTT1 and prostate cancer, we conducted a meta-analysis of 33 studies with 6,697 prostate patients and 7,643 controls. For GSTM1 null versus present genotype, the random effects odds ratio was 0.98 (95 % confidence interval (CI) 0.83–1.16) based on a wide population. Subgroup analyses in the different ethnic groups and different controls were performed. The OR was 1.01 (95 % CI 0.86–1.19) in Caucasians, 1.01 (95 % CI 0.70–1.47) in Asians, and 0.77 (95 % CI 0.42–1.42) in Africans. The OR was 0.98 (95 % CI 0.82–1.16) in non-benign prostate hyperplasia (BPH) controls and 1.09 (95 % CI 0.66–1.79) in BPH controls. In conclusion, our present meta-analysis demonstrates that there is no association between GSTT1 polymorphism and prostate cancer, even in the sub-analysis concerning different races and control sources. The direction of further research should focus not only on the simple relationship of GSTT1 and prostate cancer but also on gene–environment interaction and distinctions of different GSTs.


Prostate cancer Susceptibility Glutathione transferase GSTT1 Genetic polymorphism 


Conflicts of interest



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Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2013

Authors and Affiliations

  • Jihong Wang
    • 1
  • Yuemin Xu
    • 1
  • Qiang Fu
    • 1
  • Jianjun Yu
    • 1
  • Zhong Chen
    • 1
  • Zhangshun Liu
    • 1
  • Chao Li
    • 1
  • Hui Guo
    • 1
  • Mingkai Xie
    • 1
  1. 1.Department of Urology, Affiliated Sixth People’s HospitalShanghai Jiaotong UniversityShanghaiChina

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