Tumor Biology

, Volume 33, Issue 5, pp 1669–1680

Mammalian Sulf1 RNA alternative splicing and its significance to tumour growth regulation

  • Rai B. S. Gill
  • Amy Day
  • Amy Barstow
  • Gul Zaman
  • Chantal Chenu
  • Gurtej K. Dhoot
Research Article

Abstract

SULF1/SULF2 enzymes regulate the activities of several growth factors by selective hydrolysis of 6-O-sulphates of heparan sulphate proteoglycan co-receptors, the sulfation of which is essential for signal transduction of some ligand/receptor interactions but not others. This study demonstrates the existence of SULF1 variants with a wide spectrum of splicing patterns in mammalian tumours. The levels and relative proportions of SULF1/SULF2 splice variants markedly vary in different tumours with a potential to regulate cell growth differentially. Although mammalian Sulf1 compared with Sulf2 gene generates a much larger number of splice variants, both enzymes follow generally similar distribution and signalling association trends in hepatocellular carcinomas.

Keywords

Sulf1 splice variants Sulf2 variants Tumour growth Hepatocellular carcinoma Cell signalling 

Copyright information

© International Society of Oncology and BioMarkers (ISOBM) 2012

Authors and Affiliations

  • Rai B. S. Gill
    • 1
  • Amy Day
    • 1
  • Amy Barstow
    • 1
  • Gul Zaman
    • 1
  • Chantal Chenu
    • 1
  • Gurtej K. Dhoot
    • 1
  1. 1.Department of Basic Sciences, The Royal Veterinary CollegeUniversity of LondonLondonUK

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