MMP-7 as a prognostic marker in colorectal cancer
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Matrix metalloproteinase-7 is capable of degrading many extracellular matrix proteins and cellular adhesions. In many malignancies, it is overexpressed, and it plays a role in cancer progression by enhancing tumor invasion and thereby metastatic potential. The purpose of this study was to evaluate the association between MMP-7 tissue expression and prognosis in colorectal cancer. From 623 patients who underwent surgery for colorectal cancer, surgical specimens were collected into tissue array blocks and stained by immunohistochemistry for MMP-7. Specimens from 545 patients were suitable for analysis. In specimens from 105 patients (19.3%), MMP-7 scored as high; in 103 (18.9%), as moderate; and in 134 (24.9%), as mild. In 203 cases (37.2%), immunoreactivity was negative. A significant correlation appeared between MMP-7 immunoexpression and tumor differentiation. High MMP-7 positivity associated with poor prognosis during a 5-year follow-up. During longer follow-up, the differences in survival between groups disappeared. MMP-7 is a potential target for tumor therapy, which should be evaluated in clinical trials.
KeywordsMMP-7 Colorectal cancer Immunohistochemistry Prognosis
We thank Päivi Peltokangas, Tuire Koski, and Elina Aspiala for technical assistance.
This study was supported by Finska Läkaresällskapet, Medicinska Understödsföreningen Liv och Hälsa, and the Sigrid Jusélius Foundation.
The study has been approved by local ethics committee and complies with the Declaration of Helsinki (Dnro HUS 226/E6/06).
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