Is Rab25 a tumor promoter or suppressor—context dependency on RCP status?
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Conflicting reports in the literature suggest that Rab25 could either be a context dependent promoter or suppressor of tumorigenesis. We hypothesized that whether Rab25 acts as a promoter or suppressor in tumor progression depends on the expression status of its effector, the Rab coupling protein (RCP). An elevated expression of RCP resulting from genomic amplification may enhance Rab25’s tumor progression activity. Elevation of Rab25 alone may sequester endogenous RCP, and attenuates its activating effect on other oncogenic products, such as mutant Ras.
KeywordsRab25 Rab coupling protein (RCP) Tumor promoter Tumor suppressor
The author is grateful to the anonymous reviewers for their valuable suggestions, which improved the manuscript. He is supported by a grant from the Biomedical Research Council (BMRC) of the Agency for Science, Technology and Research (A*STAR) of Singapore (08/1/21/19/553), and declares no financial conflict of interest.
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