A polymorphism (rs2073287) of glutamate receptor, metabotropic 1 (GRM1) is associated with an increased risk of stroke in Korean population

  • Hyun-Kyung Park
  • Su Kang Kim
  • Sung Hoon Lim
  • Woo Yong Ahn
  • Geum-hee Gwak
  • Dae Jean Jo
Original Paper

Abstract

Glutamate toxicity plays a key role in neuronal cell death. The aim of this study was to investigate whether three single nucleotide polymorphisms (SNPs) (rs2073287, intron; rs2942, Lys931Lys; rs6923492, Ser993Pro) of glutamate receptor, metabotropic 1 (GRM1) were associated with the development and clinical features of stroke. We recruited 365 control subjects and 195 stroke patients consisted of 119 ischemic stroke (IS) and 76 intracerebral hemorrhage (ICH). All stroke patients were divided into clinical subgroups according to the scores of the National Institutes of Health Stroke Survey (NIHSS, < 6 and ≥ 6) and Modified Barthel Index (MBI, < 60 and ≥60). SNPStats and SPSS 18.0 were conducted to evaluate odds ratios (ORs), 95% confidence intervals (CIs), and P values. Multiple logistic regression models were performed to analyze the genetic data. A rs2073287 SNP of GRM1 was associated with the susceptibility of stroke (IS+ ICH) (P=0.002, OR=1.49, 95% CI=1.16-1.92 in allele frequencies). The rs2073287 was also associated with the development of IS (P=0.028, OR=1.40, 95% CI= 1.04-1.89 in allele frequencies) and ICH (P=0.006, OR=1.65, 95% CI=1.16–2.35 in allele frequencies). The G allele frequencies of rs2073287 in stroke (IS+ ICH), IS, and ICH were higher than in the control group, respectively. The rs2942 and rs6923492 were not related to stroke (IS+ICH), IS, and ICH, respectively. These results suggested that the G allele of rs2073287 could be a risk factor to the susceptibility of stroke in Korean population.

Keywords

Glutamate receptor Metabotropic 1(GRM1) MBI NIHSS Polymorphism Stroke 

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Copyright information

© The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Netherlands 2011

Authors and Affiliations

  • Hyun-Kyung Park
    • 1
  • Su Kang Kim
    • 2
  • Sung Hoon Lim
    • 3
  • Woo Yong Ahn
    • 4
  • Geum-hee Gwak
    • 4
  • Dae Jean Jo
    • 5
  1. 1.Department of Emergency Medicine, School of MedicineKyung Hee UniversitySeoulKorea
  2. 2.Department of Pharmacology, School of MedicineKyung Hee UniversitySeoulKorea
  3. 3.Department of Medical Engineering, Graduate SchoolKyung Hee UniversitySeoulKorea
  4. 4.Department of Biochemistry and Molecular Biology, School of MedicineKyung Hee UniversitySeoulKorea
  5. 5.Department of Neurosurgery, School of MedicineKyung Hee UniversitySeoulKorea

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