Sasa quelpaertensis leaf extract mitigates fatigue and regulates the transcriptome profile in mice
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It has been reported that various plant species may enhance the elimination of fatigue-related metabolites. However, relatively few studies have directly addressed the potential anti-fatigue effects.
The objective of this study was to investigate the anti-fatigue potential of a hot water extract of Sasa quelpaertensis Nakai leaf (SQH) in male ICR mice.
The animals were divided into three groups. The normal control (NC) group was administered saline without exercise every day for 7 days. The exercise control (EC) and exercise with SQH (ES) groups were administered saline and SQH (50 mg/kg of body weight), respectively, every day for 7 days and underwent swimming exercise. RNA sequencing technology was used to analyze the transcriptome profiles of muscle.
Swimming times were prolonged in the ES group compared with the EC group. The ES group had higher blood glucose and lower blood lactate levels, and higher muscular glycogen and lower muscular lactate levels, compared with the EC group. The groups did not differ in histopathological parameters of the muscle and liver, but muscle cell sizes were smaller in the EC group than in the ES and NC groups. RNA sequencing analysis revealed that SQH administration regulated genes associated with energy-generating metabolic pathways in skeletal muscle.
These results suggest that SQH exerts anti-fatigue properties by balancing various biological systems and helping maintain the basic harmonious pattern of the body.
KeywordsAnti-fatigue Exercise Transcriptome Sasa quelpaertensis
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) by the Ministry of Education, Science and Technology (2017R1D1A3B03029845), Republic of Korea.
- Chung WS, Kim SS, Oh JK, Lee JH, Kim KW, Jo YK, Yeon CH, Lee JS (2012) Anti-fatigue effect of fermented deer velvet antler extract in Sprague-Dawley rats. J Korean Rehabil Med 22:11–22Google Scholar
- Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 45:R80CrossRefGoogle Scholar
- Hwang JH, Choi SY, Ko HC, Jang MG, Jin YJ, Kang SI, Park JG, Chung WS, Kim SJ (2007) Anti-inflammatory effect of the hot water extract from Sasa quelpaedensis leaves. Food Sci Biotech 16:728–733Google Scholar
- Kim KM, Kim YS, Lim JY, Min SJ, Shin JH, Ko HC, Kim SJ, Lim YS, Kim Y (2014) Sasa quelpaertensis leaf extract suppresses dextran sulfate sodium–induced colitis in mice by inhibiting the proinflammatory mediators and mitogen-activated protein kinase phosphorylation. Nutr Res 34:894–905CrossRefGoogle Scholar
- Li Q, Wang Y, Cai G, Kong F, Wang X, Liu Y, Yang C, Wang D, Teng L (2015) Antifatigue activity of liquid cultured tricholoma matsutake mycelium partiall via regulation of antioxidant pathway in mouse. Biomed Res Int 2015:563245Google Scholar