Genes & Genomics

, Volume 38, Issue 2, pp 137–143 | Cite as

Resveratrol suppresses inflammatory responses and improves glucose uptake in adipocytes interacted with macrophages

  • Hye-Sun Shin
  • Seong-Il Kang
  • Deok-bae Park
  • Se-Jae Kim
Research Article


Obesity is associated with inflammatory status and linked with metabolic syndrome. Interaction between adipocytes and macrophages aggravates inflammation and leads to insulin resistance in adipocytes. Resveratrol improved reportedly obesity-related inflammatory responses, but the effects of resveratrol on the production of inflammatory mediators and glucose metabolism in inflamed adipose tissue is not completely known. In this study, we investigated the effects of resveratrol on inflammatory change and insulin resistance in the coculture of hypertrophied 3T3-L1 adipocytes and RAW 264.7 macrophages. Resveratrol decreased nitric oxide production and the expression of interleukin (IL)-6, IL-1β, tumor necrosis factor-α, inducible nitric oxide synthesis, and cyclooxygenase-2 in the coculture. Resveratrol increased glucose uptake by stimulating the phosphorylation of IRS-1 and AKT in the coculture. These results support that resveratrol have beneficial effect on inflammation and insulin resistance in inflamed adipose tissue.


Resveratrol Adipocytes Macrophages Inflammation Glucose uptake 



This research was supported by the 2015 scientific promotion program funded by Jeju National University.

Compliance with ethical standards

Conflict of interest

The authors declare no conflict of interest.


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Copyright information

© The Genetics Society of Korea and Springer-Science and Media 2015

Authors and Affiliations

  • Hye-Sun Shin
    • 1
  • Seong-Il Kang
    • 1
  • Deok-bae Park
    • 2
  • Se-Jae Kim
    • 1
  1. 1.Department of BiologyJeju National UniversityJejuKorea
  2. 2.Department of MedicineJeju National UniversityJejuKorea

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