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Genes & Genomics

, Volume 37, Issue 12, pp 985–989 | Cite as

Study of the relationship between variants near CCNL1/LEKR1 and in ADCY5 with low birth weight in a Chinese population

  • Xuejin Fan
  • Qi Peng
  • Yanhua Chen
  • Zeke Ma
  • Xiaoguang He
  • Biying Deng
  • Hui Huang
  • Juan Zeng
  • Chuyun Cheng
  • Shaoji Liu
  • Xiaomei LuEmail author
Research Article

Abstract

The aim of this study was to test the impact of variants rs900400 (located near LEKR1 and CCNL1) and rs9883204 (located in ADCY5) on birth weight in a Chinese population. We conducted a case–control study including 156 low-birth- weight infants as the case group and 100 normal-birth-weight infants as the control group. The rs900400 and rs9883204 variants were analyzed by gene sequencing in all the participants. Our results revealed a significant difference in the genotype distribution (χ2 = 10.449, p = 0.005) and allele distribution (χ2 = 9.277, p = 0.002) of rs900400 between the case group and the control group. The C allele of rs900400 was associated with lower birth weight (OR 1.771 [95 % CI 1.237–2.535]) in the Chinese population. However, the rs9883204 polymorphism was not informative in the Chinese population. Our study shows that the “birth weight-lowering” variant rs900400 located near LEKR1 and CCNL1, which is strongly associated with birth weight in European cohorts, appears to have a similar association in Chinese cohorts. However, the rs9883204 variant located in ADCY5 does not appear to be correlated with low birth weight in the same population. Moreover, we found that the variant rs900400 may also be associated with premature birth, thereby supporting the need for further research in this area.

Keywords

Low birth weight Candidate gene SNP association Case–control 

Notes

Acknowledgments

We are grateful for the participation of all the patients and their families. This work was partially supported by the Dongguan Bureau of Science and Technology for the City Key Program of Science and Technology (Project Number: 2012105102026).

Compliance with ethical standards

Conflict of Interest

The authors declare that they have no conflict of interest.

Ethics Statement

The study was approved by the Institutional Ethics Committee of the Eighth People’s Hospital of Dongguan (Children’s Hospital of Dongguan). Informed written consent was obtained from the parents or guardians on behalf of the infant participants.

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Copyright information

© The Genetics Society of Korea and Springer-Science and Media 2015

Authors and Affiliations

  • Xuejin Fan
    • 1
  • Qi Peng
    • 2
  • Yanhua Chen
    • 3
  • Zeke Ma
    • 1
  • Xiaoguang He
    • 1
  • Biying Deng
    • 1
  • Hui Huang
    • 3
  • Juan Zeng
    • 1
  • Chuyun Cheng
    • 4
  • Shaoji Liu
    • 1
  • Xiaomei Lu
    • 2
    Email author
  1. 1.Department of PediatricsThe Eighth People’s Hospital of DongguanDongguanChina
  2. 2.Dongguan Institute of PediatricsDongguanChina
  3. 3.BGI-ShenzhenShenzhenChina
  4. 4.Department of Obstetrics and GynecologyThe Eighth People’s Hospital of DongguanDongguanChina

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