Genes & Genomics

, Volume 37, Issue 2, pp 173–181 | Cite as

Effect of interactions between genetic polymorphisms and cigarette smoking on plasma triglyceride levels in elderly Koreans: the Hallym Aging Study

  • Eun Pyo Hong
  • Ji Wan Park
  • Jun-Gyo Suh
  • Dong-Hyun Kim
Research Article
First Online:
Received:
Accepted:

Abstract

High triglyceride (TG) levels are known to be associated with complex diseases such as cardiovascular disease. Here, we evaluated the effect of interactions between genetic polymorphisms and environmental factors on plasma TG levels in a Korean aging cohort. Thirty-two single nucleotide polymorphism (SNP) markers located in seven genes (ADLH2, APOE, GCKR, MC4R, TCF7L2, GATA2, and HNF1A) for TG levels were genotyped in 714 older Koreans (mean age, 68 years). We performed multiple linear regression analyses for these SNP markers under three genetic models (i.e. additive, dominant, and recessive) and evaluated their associations with multiple environmental factors, including obesity, systolic blood pressure, and drinking and smoking habits. We found evidence for four SNP-smoking interactions. The CC genotype of rs1260326 (GCKR) interacted with current smoking for lower TG levels (P G×E = 0.017). TG levels were higher in smokers with the GG genotype of rs2713604 (GATA2) than in those with the GA + AA genotypes (195.6 and 145.7 mg/dL, respectively, P G×E = 0.029). The GA + AA genotypes of rs2713603 (GATA2) were associated with elevated TG levels in smokers when compared to non-smokers carrying the GG genotype (180.6 mg/dL vs. 148.3 mg/dL, P G×E = 0.046). The C allele of rs2464196 (HNF1A) interacted with current smoking for elevated TG levels (P G×E = 0.028). The gene and cigarette smoking interactions shown in this study need to be validated in a large-scale study.

Keywords

Aging cohort Cigarette smoking Gene-environment interaction Single nucleotide polymorphism Triglycerides 
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Notes

Acknowledgments

This work was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology, Republic of Korea (2009-0090837) and the Hallym University Research Fund 2012 (HRF-G2012-5).

Conflict of interest

None declared.

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Copyright information

© The Genetics Society of Korea and Springer-Science and Media 2014

Authors and Affiliations

  • Eun Pyo Hong
    • 1
  • Ji Wan Park
    • 1
  • Jun-Gyo Suh
    • 1
  • Dong-Hyun Kim
    • 2
    • 3
  1. 1.Department of Medical Genetics, College of MedicineHallym UniversityChuncheonRepublic of Korea
  2. 2.Department of Social and Preventive Medicine, College of MedicineHallym UniversityChuncheonRepublic of Korea
  3. 3.Hallym Research Institute of Clinical EpidemiologyHallym UniversityChuncheonRepublic of Korea

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