Genes & Genomics

, 33:133 | Cite as

Association of the vascular endothelial growth factor (VEGF-1154G>A) polymorphism in patients with colorectal cancer

  • Yi Seul Choi
  • Jeong-Kwon Choi
  • Jong Woo Kim
  • Kyung Tae Min
  • Young Do Kwon
  • Moon Ju Jang
  • So Young Chong
  • Doyeun Oh
  • Yoon Kyung Cho
  • Seung Ho Hong
  • Nam Keun Kim
Research Article
First Online:
Received:
Accepted:

Abstract

Angiogenesis plays a pivotal role in the development of colon cancer during the promotion and metastasis of tumor growth. Vascular endothelial growth factor (VEGF) is known to be a potent angiogenic factor. This hospital-based case-control study was carried out to decide where there existed an association between the VEGF-1154G>A polymorphism and the susceptibility to colon cancer. DNA samples taken from 278 colon cancer patients and 226 healthy controls were studied using with real-time PCR for VEGF-1154G>A polymorphism. Genotype frequencies of the VEGF-1154G>A polymorphism were significantly different between patient and control groups (adjusted OR=2.735, 95% CI=1.243−6.015 for AA vs. GG genotype). In addition, upon stratification by gender and age, the frequencies of the A allele-bearing genotypes significantly increased the risk for development of colon cancer in men and patients younger than 55 years (in men, adjusted OR=3.375, 95% CI=1.062−10.717, and in <55 years, adjusted OR=4.908, 95% CI=1.294−18.617). Also, upon stratification of patients with proximal and distal colon cancer individually, the association only showed these significant patterns in distal colon cancer. This study provides evidence that VEGF-1154G>A polymorphism, at least in Koreans, might be associated with risks of the colon cancer, particularly in males.

Keywords

Colon cancer Vascular endothelial growth factor (VEGF) Polymorphism Korean 
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Copyright information

© The Genetics Society of Korea and Springer Netherlands 2011

Authors and Affiliations

  • Yi Seul Choi
    • 1
  • Jeong-Kwon Choi
    • 1
  • Jong Woo Kim
    • 2
  • Kyung Tae Min
    • 1
  • Young Do Kwon
    • 1
  • Moon Ju Jang
    • 1
    • 3
  • So Young Chong
    • 3
  • Doyeun Oh
    • 3
  • Yoon Kyung Cho
    • 4
  • Seung Ho Hong
    • 5
  • Nam Keun Kim
    • 1
  1. 1.Institute for Clinical Research, School of MedicineCHA UniversitySeongnamKorea
  2. 2.Department of Surgery, School of MedicineCHA UniversitySeongnamKorea
  3. 3.Department of Internal Medicine, School of MedicineCHA UniversitySeongnamKorea
  4. 4.Department of Internal Medicine, CHA Gangnam Medical CenterCHA UniversitySeoulKorea
  5. 5.Department of Science Education, Teachers CollegeJeju National UniversityJejuKorea

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