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Bayesian Semiparametric Model for Pathway-Based Analysis with Zero-Inflated Clinical Outcomes

  • Lulu Cheng
  • Inyoung KimEmail author
  • Herbert Pang
Article

Abstract

In this paper, we propose a semiparametric regression approach for identifying pathways related to zero-inflated clinical outcomes, where a pathway is a gene set derived from prior biological knowledge. Our approach is developed by using a Bayesian hierarchical framework. We model the pathway effect nonparametrically into a zero-inflated Poisson hierarchical regression model with an unknown link function. Nonparametric pathway effect was estimated via a kernel machine, and the unknown link function was estimated by transforming a mixture of the beta cumulative density function. Our approach provides flexible nonparametric settings to describe the complicated association between gene expressions and zero-inflated clinical outcomes. The Metropolis-within-Gibbs sampling algorithm and Bayes factor were adopted to make statistical inferences. Our simulation results support that our semiparametric approach is more accurate and flexible than zero-inflated Poisson regression with the canonical link function, which is especially true when the number of genes is large. The usefulness of our approach is demonstrated through its applications to the Canine data set from Enerson et al. (Toxicol Pathol 34:27–32, 2006). Our approach can also be applied to other settings where a large number of highly correlated predictors are present.

Supplementary materials accompanying this paper appear on-line.

Keywords

Gaussian process Marginal likelihood Mixed model Unknown link Pathway based analysis Zero-inflated poisson 

Notes

Acknowledgments

This study was partially supported by grants from the National Science Foundation (CNS-096480 and CNS-1115839).

Supplementary material

13253_2016_264_MOESM1_ESM.pdf (581 kb)
Supplementary material 1 (pdf 581 KB)

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Copyright information

© International Biometric Society 2016

Authors and Affiliations

  1. 1.Department of StatisticsVirginia Polytechnic Institute and State University (Virginia Tech.)BlacksburgUSA
  2. 2.Division of Epidemiology and Biostatistics, School of Public HealthThe University of Hong KongPokfulamHong Kong

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