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Practical time considerations for optically stimulated luminescent dosimetry (OSLD) in total body irradiation

  • Martin ButsonEmail author
  • Mamoon Haque
  • Leon Smith
  • Ethan Butson
  • David Odgers
  • Dane Pope
  • Tina Gorjiana
  • May Whitaker
  • Johnny Morales
  • Angela Hong
  • Robin Hill
Scientific Note

Abstract

Total body irradiation (TBI) treatments are used to treat the whole body in preparation for hematopoietic stem cell (or bone marrow) transplantation. Our standard clinical regimen is a 12 Gy in 6 fraction, bi-daily technique using 6 MV X-rays at an extended Source-to-Surface distance (SSD) of 300 cm. Utilizing these characteristics, the beam dose rate is reduced below 7 cGy/min as is standard for TBI treatment. Dose received by the patient is monitored using optically stimulated luminescent dosimetry (OSLD). This work presents some practical calibration corrections based on time-dependant factors for OSLD calibration related to TBI procedure. Results have shown that a negligible difference is seen in OSL sensitivity for 6 MV X-rays irradiated in standard SSD (100 cm) and high dose rate (600 cGy/min) conditions compared to extended SSD (300 cm) and low TBI dose rate (6 cGy/min) conditions. Results have also shown that whilst short term signal fading occurs in the OSL after irradiation at a high dose rate (37% reduction in signal in the first 15 min), thereafter, negligible differences are seen in the OSL signal between 600 and 7 cGy/min irradiations. Thus a direct comparison can be made between calibration OSLs and clinical TBI OSLs between 15 min and 2 h. Finally a table is presented to provide corrections between calibration OSL readout and clinical TBI dose readout for a period up to 7 days. Combining these three results allows users to pre-irradiate their calibration OSLs at standard dose rate and SSD, up to 1 week prior to clinical treatment, and still provide accurate in-vivo dosimetry. This can help with time saving and work efficiency in the clinic.

Keywords

Dosimetry Radiation Total body irradiation OSL 

Notes

Compliance with Ethical Standards

Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

References

  1. 1.
    Eaton DJ, Warry AJ, Trimble RE, Vilarino-Varela MJ, Collis CH (2014) Benefits of online in vivo dosimetry for single-fraction total body irradiation. Med Dosim 39:354–359CrossRefPubMedGoogle Scholar
  2. 2.
    Mangili P, Fiorino C, Rosso A, Cattaneo GM, Parisi R, Villa E, Calandrino R (1999) In-vivo dosimetry by diode semiconductors in combination with portal films during TBI: reporting a 5-year clinical experience. Radiother Oncol 52:269–276CrossRefPubMedGoogle Scholar
  3. 3.
    Lancaster CM, Crosbie JC, Davis SR (2008) In-vivo dosimetry from total body irradiation patients (2000–2006): results and analysis. Australas Phys Eng Sci Med 31:191–5CrossRefPubMedGoogle Scholar
  4. 4.
    Mahmoud Allahverdi M, Ghazale Geraily G, Mahbod Esfehani M, Aliakbar Sharafi A, Peyman Haddad P, Alireza S (2007) Dosimetry and verification of 60Co total body irradiation with human phantom and semiconductor diodes. J Med Phys 32:169–174CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Briere TM, Tailor R, Tolani N, Prado K, Lane R, Woo S, Ha C, Gillin MT, Beddar AS (2008) Patient dosimetry for total body irradiation using single-use MOSFET detectors. J Appl Clin Med Phys 9:2787CrossRefPubMedGoogle Scholar
  6. 6.
    Su FC, Shi C, Papanikolaou N (2008) Clinical application of GAFCHROMIC EBT film for in vivo dose measurements of total body irradiation radiotherapy. Appl Radiat Isot 66:389–394CrossRefPubMedGoogle Scholar
  7. 7.
    Niedbala M, Save C, Cygler J (2014) In vivo dosimetry for total body and total marrow irradiations with optically stimulated luminescence dosimeters. Med Phys 41:365CrossRefGoogle Scholar
  8. 8.
    Holloway C, Mahendra S, Kaurin D, Sweeney L (2013) Total body irradiation (TBI) optically stimulated luminescence in vivo dosimetry. Med Phys 40:223CrossRefGoogle Scholar
  9. 9.
    Esquivel C, Stathakis S, Gutierrez A, Shi C, Smith M, Papanikolaou N (2009) Clinical experience in the use of optically stimulated luminescent dosimeters for total body irradiation. Int J Radiat Oncol Biol Phys 75(3):S602–S603CrossRefGoogle Scholar
  10. 10.
    Dunn L, Lye J, Kenny J, Lehmann J, Williams I, Kron T (2013) Commissioning of optically stimulated luminescence dosimeters for use in radiotherapy. Radiat Meas 51–52:31–39CrossRefGoogle Scholar

Copyright information

© Australasian College of Physical Scientists and Engineers in Medicine 2017

Authors and Affiliations

  • Martin Butson
    • 1
    • 2
    Email author
  • Mamoon Haque
    • 1
    • 2
  • Leon Smith
    • 3
  • Ethan Butson
    • 2
  • David Odgers
    • 1
  • Dane Pope
    • 1
  • Tina Gorjiana
    • 1
  • May Whitaker
    • 1
  • Johnny Morales
    • 1
    • 4
  • Angela Hong
    • 1
    • 3
  • Robin Hill
    • 1
    • 2
  1. 1.Dept of Radiation OncologyChris O’Brien LifehouseCamperdownAustralia
  2. 2.Institute of Medical PhysicsUniversity of SydneyCamperdownAustralia
  3. 3.Sydney Medical SchoolUniversity of SydneyCamperdownAustralia
  4. 4.School of Chemistry, Physics and Mechanical EngineeringQueensland University of TechnologyBrisbaneAustralia

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