Multi-Objective Optimization Design of Balloon-Expandable Coronary Stent
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Recent studies suggested that suboptimal delivery and longitudinal stent deformation can result in in-stent restenosis. Therefore, the purpose of this paper was to study the effect of stent geometry on stent flexibility and longitudinal stiffness (LS) and optimize the two metrics simultaneously. Then, the reliable and accurate relationships between metrics and design variables were established.
A multi-objective optimization method based on finite element analysis was proposed for the investigation and improvement of stent flexibility and LS. The relative influences of design variables on the two metrics were evaluated on the basis of the main effects. Three surrogate models, namely, the response surface model (RSM), radial basis function neural network (RBF), and Kriging were employed and compared.
The accuracies of the three models in fitting flexibility were nearly similar, although Kriging made more accurate prediction in LS. The link width played important roles in flexibility and LS. Although the flexibility of the optimal stent decreased by 13%, the LS increased by 48.3%.
The obtained results showed that the multi-objective optimization method is efficient in predicting an optimal stent design. The method presented in this paper can be useful in optimizing stent design and improving the comprehensive mechanical properties of stents.
KeywordsCoronary stents Multi-objective optimization Flexibility Longitudinal stiffness
This project is supported by the National Natural Science Foundation of China (51305171), Natural Science Foundation of Jiangsu Province (BK20130525), Natural Science Foundation of the Higher Education Institutions of Jiangsu Province (13KJB460006), China Postdoctoral Science Foundation (2011M500858), Foundation of Jiangsu University (10JDG123) and Project of Jiangsu University for training young backbone teachers.
Conflict of interest
Xiang Shen, Hongfei Zhu, Jiabao Jiang, Yongquan Deng and Song Ji declare that they have no conflict of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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